ArticleThe Plant cell2023
Multiple cyclic nucleotide-gated channels function as ABA-activated Ca2+ channels required for ABA-induced stomatal closure in Arabidopsis.
Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 69 citations in OpenAlex.
- Review
- Cyclic nucleotide-gated channels 14, 15, and 16 coordinate multiple signaling pathways to promote salt tolerance in rice.The Plant journal : for cell and molecular biology · 2026Article
- Synthetic ion channel inhibitors enhance plant drought tolerance.Nature communications · 2026Article
- Genome-Wide Identification ofPlants (Basel, Switzerland) · 2026Article
- A BRI1-CNGC12 phosphorylation module links hormone signaling to manganese homeostasis in plants.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cyclic nucleotide-gated channels serve as core components for CaJournal of plant research · 2026Article
- Abscisic Acid and Calcium Signals Convergently Regulate Sugar Accumulation by Orchestrating the SRK2A/CIPK6-ABI5-TST2 Module in Citrus.Plant biotechnology journal · 2026Article
- A drought stress-responsive metabolite malate modulates stomatal responses through G-protein-dependent pathway in grapevine and Arabidopsis.Molecular horticulture · 2026Article
- MAP4K1 and MAP4K2 regulate ABA-induced and CaScience advances · 2025Article
- Roles of ROS and NO in Plant Responses to Individual and Combined Salt Stress and Waterlogging.Antioxidants (Basel, Switzerland) · 2025Review
- OPEN STOMATA 1 activates SLAC1 anion channel primarily through CPK15 in ABA-induced stomatal closure inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Stomatal signaling under drought: integrating hormonal pathways for crop resilience.Plant cell reports · 2025Review
- Sowing Methods and Strigolactones Alleviate Damage to the Photosynthetic System of Rice Seedlings Under Salt Stress by Enhancing Antioxidant Capacity.Antioxidants (Basel, Switzerland) · 2025Article
- Intra species dissection of phytophthora capsici resistance in black pepper.Journal of advanced research · 2025Article
- SnRK2s: Kinases or Substrates?Plants (Basel, Switzerland) · 2025Review
- Genome-wide identification of SlIQMs and the regulatory effect of calcium on tomato seedlings under drought stress and phytohormone treatment.Plant cell reports · 2025Article
- Cryo-EM structures of Arabidopsis CNGC1 and CNGC5 reveal molecular mechanisms underlying gating and calcium selectivity.Nature plants · 2025Article
- Analysis ofInternational journal of molecular sciences · 2025Article
- CPK1 activates CNGCs through phosphorylation for CaNature communications · 2025Article
- ABA-activated low-nanomolar CaNature plants · 2025Article
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8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abscisic acid (ABA)-activated inward Ca2+-permeable channels in the plasma membrane (PM) of guard cells are required for the initiation and regulation of ABA-specific cytosolic Ca2+ signaling and stomatal closure in plants. But the identities of the PM Ca2+ channels are still unknown. We hypothesized that the ABA-activated Ca2+ channels consist of multiple CYCLIC NUCLEOTIDE-GATED CHANNEL (CNGC) proteins from the CNGC family, which is known as a Ca2+-permeable channel family in Arabidopsis (Arabidopsis thaliana). In this research, we observed high expression of multiple CNGC genes in Arabidopsis guard cells, namely CNGC5, CNGC6, CNGC9, and CNGC12. The T-DNA insertional loss-of-function quadruple mutant cngc5-1 cngc6-2 cngc9-1 cngc12-1 (hereafter c5/6/9/12) showed a strong ABA-insensitive phenotype of stomatal closure. Further analysis revealed that ABA-activated Ca2+ channel currents were impaired, and ABA-specific cytosolic Ca2+ oscillation patterns were disrupted in c5/6/9/12 guard cells compared with in wild-type guard cells. All ABA-related phenotypes of the c5/6/9/12 mutant were successfully rescued by the expression of a single gene out of the four CNGCs under the respective native promoter. Thus, our findings reveal a type of ABA-activated PM Ca2+ channel comprising multiple CNGCs, which is essential for ABA-specific Ca2+ signaling of guard cells and ABA-induced stomatal closure in Arabidopsis.
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