ArticleeLife2022
Poxviruses capture host genes by LINE-1 retrotransposition.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The evolutionary dynamics between viral mimics and host proteins.Molecular systems biology · 2026Article
- An ancient lysozyme in placozoans participates in acidic extracellular digestion.Communications biology · 2026Article
- Antagonistic co-evolution throughout the herpesvirus life cycle.Virus evolution · 2026Review
- The silent spread: uncovering the diversity and evolution of poxviruses in ticks across Western China's host landscapes.Virology journal · 2025Article
- Review
- Human cytomegalovirus harnesses host L1 retrotransposon for efficient replication.Nature communications · 2024Article
- Human cytomegalovirus harnesses host L1 retrotransposon for efficient replication.Nature communications · 2024Article
- Evolutionary Dynamics of Accelerated Antiviral Resistance Development in Hypermutator Herpesvirus.Molecular biology and evolution · 2024Article
- Eptesipox virus-associated lesions in naturally infected big brown bats.Veterinary pathology · 2024Article
- Molecular evolution of 2022 multi-country outbreak-causing monkeypox virus Clade IIb.iScience · 2024Article
- Evolution of theVirus evolution · 2024Article
- Phylogenetic diversity and functional potential of large and cell-associated viruses in the Bay of Bengal.mSphere · 2023Article
- Virologs, viral mimicry, and virocell metabolism: the expanding scale of cellular functions encoded in the complex genomes of giant viruses.FEMS microbiology reviews · 2023Article
- Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity.Cell reports · 2023Article
- Vertebrate-tropism of a cressdnavirus lineage implicated by poxvirus gene capture.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Structural homology screens reveal poxvirus-encoded proteins impacting inflammasome-mediated defenses.bioRxiv : the preprint server for biology · 2023Article
- Molecular Mechanisms of Poxvirus Evolution.mBio · 2023Review
- Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions.Science advances · 2022Article
- A life LINE for large viruses.eLife · 2022Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Horizontal gene transfer (HGT) provides a major source of genetic variation. Many viruses, including poxviruses, encode genes with crucial functions directly gained by gene transfer from hosts. The mechanism of transfer to poxvirus genomes is unknown. Using genome analysis and experimental screens of infected cells, we discovered a central role for Long Interspersed Nuclear Element-1 retrotransposition in HGT to virus genomes. The process recapitulates processed pseudogene generation, but with host messenger RNA directed into virus genomes. Intriguingly, hallmark features of retrotransposition appear to favor virus adaption through rapid duplication of captured host genes on arrival. Our study reveals a previously unrecognized conduit of genetic traffic with fundamental implications for the evolution of many virus classes and their hosts.
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