Evidence map›Paper›PMID 36069432›Full record

ArticlePediatric blood & cancer2022

Feasibility of oncology clinical trial-embedded evaluation of social determinants of health.

Rahela Aziz-Bose, Daniel J Zheng, Puja J Umaretiya, Lenka Ilcisin, Kristen Stevenson, Victoria Koch, Ariana Valenzuela, Peter D Cole, Lisa M Gennarini, Justine M Kahn and 7 more

Abstract readMulticenter Study
In one paragraph

Article in Pediatric blood & cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Targeting hardship: poverty as a modifiable risk factor in childhood leukemia and lymphoma treatment.Hematology. American Society of Hematology. Education Program · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rahela Aziz-BoseDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID 0000-0003-4753-5144
Daniel J ZhengDivisions of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Puja J UmaretiyaDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID 0000-0002-7587-4875
Lenka IlcisinDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID 0000-0001-8934-5029
Kristen StevensonDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Victoria KochDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Ariana ValenzuelaDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Peter D ColeDivision of Pediatric Hematology/Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.ORCID 0000-0002-3525-8015
Lisa M GennariniDivision of Pediatric Hematology/Oncology and Blood & Marrow Cell Transplantation, Montefiore Medical Center, Bronx, New York, USA.
Justine M KahnDivision of Pediatric Hematology, Oncology and Stem Cell Transplantation, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0003-3330-6754
Kara M KellyDepartment of Pediatrics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Thai-Hoa TranDivision of Pediatric Hematology-Oncology, Charles-Bruneau Cancer Center, CHU Ste-Justine, University of Montreal, Montreal, QC, Canada.ORCID 0000-0002-8712-6233
Bruno MichonDepartment of Pediatrics, Centre Hospitalier Universitaire de Quebec, Saint-Foy, QC, Canada.
Jennifer J G WelchDivision of Pediatric Hematology/Oncology, Hasbro Children's Hospital/Brown University, Providence, Rhode Island, USA.
Lewis B SilvermanDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Joanne WolfeDivision of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-4406-7413
Kira BonaDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.ORCID 0000-0001-5602-7059

Funding

Research Training in Pediatric OncologyT32CA136432 · NCI · DANA-FARBER CANCER INST · PI SCOTT A ARMSTRONG · 2009 to 2026
$7.9M
Material Hardship as a Targetable Measure of Poverty in Pediatric CancerK07CA211847 · NCI · DANA-FARBER CANCER INST · PI BONA, KIRA O. · 2016 to 2021
$731k
NCI NIH HHS K07 CA211847NCI NIH HHS T32 CA136432
6 · The paper itself

Abstract

Social determinants of health (SDoH) are associated with stark disparities in cancer outcomes, but systematic SDoH data collection is virtually absent from oncology clinical trials. Trial-based SDoH data are essential to ensure representation of marginalized populations, contextualize outcome disparities, and identify health-equity intervention opportunities. We report the feasibility of a pediatric oncology multicenter therapeutic trial-embedded SDoH investigation. Among 448 trial participants, 392 (87.5%) opted-in to the embedded SDoH study; 375 (95.7%) completed baseline surveys, with high longitudinal response rates (88.9-93.1%) over 24 months. Trial-embedded SDoH data collection is feasible and acceptable and must be consistently included within future oncology trials.

Indexed as

NeoplasmsSocial Determinants of HealthChildFeasibility StudiesHealth Status DisparitiesHumanshealth equityresearch methodssocial determinants of health

Identifiers

PMID36069432
PMCPMC11706206

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.