Evidence map›Paper›PMID 36069406›Full record

ArticleJournal of agricultural and food chemistry2022

Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine.

Katja C W van Dongen, Clara Belzer, Wouter Bakker, Ivonne M C M Rietjens, Karsten Beekmann

Abstract read
In one paragraph

Article in Journal of agricultural and food chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katja C W van DongenDivision of Toxicology, Wageningen University and Research, P.O. Box 8000, Wageningen 6700 EA, The Netherlands.ORCID 0000-0002-0718-4653
Clara BelzerLaboratory of Microbiology, Wageningen University and Research, P.O. Box 8033, Wageningen 6700 EH, The Netherlands.
Wouter BakkerDivision of Toxicology, Wageningen University and Research, P.O. Box 8000, Wageningen 6700 EA, The Netherlands.ORCID 0000-0002-0345-111X
Ivonne M C M RietjensDivision of Toxicology, Wageningen University and Research, P.O. Box 8000, Wageningen 6700 EA, The Netherlands.
Karsten BeekmannWageningen Food Safety Research (WFSR), Part of Wageningen University and Research, P.O. Box 230, Wageningen 700 AE, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advanced glycation endproduct carboxymethyllysine and its precursor fructoselysine are present in heated, processed food products and are considered potentially hazardous for human health. Upon dietary exposure, they can be degraded by human colonic gut microbiota, reducing internal exposure. Pronounced interindividual and intraindividual differences in these metabolic degradations were found in anaerobic incubations with human fecal slurries in vitro. The average capacity to degrade fructoselysine was 27.7-fold higher than that for carboxymethyllysine, and degradation capacities for these two compounds were not correlated (

Indexed as

Gastrointestinal MicrobiomeFecesGlycation End Products, AdvancedHumansLysineRNA, Ribosomal, 16Sfructosyl-lysineGlycation End Products, AdvancedLysineN(6)-carboxymethyllysineRNA, Ribosomal, 16S16S rRNA analysisadvanced glycation end producthuman gut microbiotainterindividual differencesintraindividual differencesnew approach methodologiestemporal variability

Identifiers

PMID36069406
PMCPMC9501902

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.