ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2022
Direct Assessment of Rabbit Cortical Bone Basic Multicellular Unit Longitudinal Erosion Rate: A 4D Synchrotron-Based Approach.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- 3D morphological analysis of age and sex-related changes in human cortical bone remodeling spaces using micro-CT.Journal of anatomy · 2026Article
- Balanced Basic Multicellular Unit Activity in Cortical Bone of Ovariohysterectomized Rabbits.Calcified tissue international · 2025Article
- A robust deep learning approach for segmenting cortical and trabecular bone from 3D high resolution µCT scans of mouse bone.Scientific reports · 2025Article
- Hard X-ray imaging and tomography at the Biomedical Imaging and Therapy beamlines of Canadian Light Source.Journal of synchrotron radiation · 2024Article
- Bridging the Gap in Understanding Bone Metastasis: A Multifaceted Perspective.International journal of molecular sciences · 2024Review
- Low-density tissue scaffold imaging by synchrotron radiation propagation-based imaging computed tomography with helical acquisition mode.Journal of synchrotron radiation · 2023Article
- Advances in Animal Models for Studying Bone Fracture Healing.Bioengineering (Basel, Switzerland) · 2023Review
- MRI overestimates articular cartilage thickness and volume compared to synchrotron radiation phase-contrast imaging.PloS one · 2023Article
- Direct Assessment of Rabbit Cortical Bone Basic Multicellular Unit Longitudinal Erosion Rate: A 4D Synchrotron-Based Approach.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Cortical bone remodeling is carried out by basic multicellular units (BMUs), which couple resorption to formation. Although fluorochrome labeling has facilitated study of BMU formative parameters since the 1960s, some resorptive parameters, including the longitudinal erosion rate (LER), have remained beyond reach of direct measurement. Indeed, our only insights into this spatiotemporal parameter of BMU behavior come from classical studies that indirectly inferred LER. Here, we demonstrate a 4D in vivo method to directly measure LER through in-line phase contrast synchrotron imaging. The tibias of rabbits (n = 15) dosed daily with parathyroid hormone were first imaged in vivo (synchrotron micro-CT; day 15) and then ex vivo 14 days later (conventional micro-CT; day 29). Mean LER assessed by landmarking the co-registered scans was 23.69 ± 1.73 μm/d. This novel approach holds great promise for the direct study of the spatiotemporal coordination of bone remodeling, its role in diseases such as osteoporosis, as well as related treatments. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
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