Evidence map›Paper›PMID 36069183›Full record

ArticleStroke2022

Red Blood Cell Microparticles Limit Hematoma Growth in Intracerebral Hemorrhage.

Ashish K Rehni, Sunjoo Cho, Hever Navarro Quero, Vibha Shukla, Zhexuan Zhang, Chuanhui Dong, Weizhao Zhao, Miguel A Perez-Pinzon, Sebastian Koch, Wenche Jy and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Ashish K RehniPeritz Scheinberg Cerebral Vascular Disease Research Laboratories (A.K.R., S.C., V.S., M.A.P.-P., K.R.D.), University of Miami Miller School of Medicine, FL.ORCID 0000-0002-9107-3277
Sunjoo ChoPeritz Scheinberg Cerebral Vascular Disease Research Laboratories (A.K.R., S.C., V.S., M.A.P.-P., K.R.D.), University of Miami Miller School of Medicine, FL.
Hever Navarro QueroThe Wallace H Coulter Platelet Laboratory, Division of Hematology/Oncology, Department of Medicine (H.N.Q., W.J.), University of Miami Miller School of Medicine, FL.
Vibha ShuklaPeritz Scheinberg Cerebral Vascular Disease Research Laboratories (A.K.R., S.C., V.S., M.A.P.-P., K.R.D.), University of Miami Miller School of Medicine, FL.
Zhexuan ZhangDepartment of Biomedical Engineering, University of Miami, Coral Gables, FL (Z.Z., W.Z.).ORCID 0000-0002-8149-9186
Chuanhui DongDepartment of Neurology (A.K.R., S.C., V.S, C.D., M.A.P.-P., S.K., K.R.D.), University of Miami Miller School of Medicine, FL.
Weizhao ZhaoDepartment of Biomedical Engineering, University of Miami, Coral Gables, FL (Z.Z., W.Z.).ORCID 0000-0002-9890-5785
Miguel A Perez-PinzonPeritz Scheinberg Cerebral Vascular Disease Research Laboratories (A.K.R., S.C., V.S., M.A.P.-P., K.R.D.), University of Miami Miller School of Medicine, FL.ORCID 0000-0001-6555-8935
Sebastian KochDepartment of Neurology (A.K.R., S.C., V.S, C.D., M.A.P.-P., S.K., K.R.D.), University of Miami Miller School of Medicine, FL.
Wenche JyThe Wallace H Coulter Platelet Laboratory, Division of Hematology/Oncology, Department of Medicine (H.N.Q., W.J.), University of Miami Miller School of Medicine, FL.
Kunjan R DavePeritz Scheinberg Cerebral Vascular Disease Research Laboratories (A.K.R., S.C., V.S., M.A.P.-P., K.R.D.), University of Miami Miller School of Medicine, FL.ORCID 0000-0002-0173-5338
University of Miami · US

Funding

Red blood cell microparticles (RMPs) to reduce bleeding following hemorrhagic strokeR33NS094896 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DAVE, KUNJAN R · 2017 to 2018
$835k
Red blood cell microparticles (RMPs) to reduce bleeding following hemorrhagic strokeR21NS094896 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DAVE, KUNJAN R · 2016 to 2016
$307k
NINDS NIH HHS R21 NS094896NINDS NIH HHS R33 NS094896
6 · The paper itself

Abstract

backgroundSpontaneous intracerebral hemorrhage (sICH) is the deadliest stroke subtype with no effective therapies. Limiting hematoma expansion is a promising therapeutic approach. Red blood cell-derived microparticles (RMPs) are novel hemostatic agents. Therefore, we studied the potential of RMPs in limiting hematoma growth and improving outcomes post-sICH.

methodssICH was induced in rats by intrastriatal injection of collagenase. RMPs were prepared from human RBCs by high-pressure extrusion. Behavioral and hematoma/lesion volume assessment were done post-sICH. The optimal dose, dosing regimen, and therapeutic time window of RMP therapy required to limit hematoma growth post-sICH were determined. We also evaluated the effect of RMPs on long-term behavioral and histopathologic outcomes post-sICH.

resultsRMP treatment limited hematoma growth following sICH. Hematoma volume (mm

conclusionsOur results demonstrate that RMP therapy limits hematoma growth and improves outcomes post-sICH in a rodent model. Therefore, RMPs have the potential to limit hematoma growth in sICH patients.

Indexed as

Cell-Derived MicroparticlesHemostaticsAnimalsCerebral HemorrhageErythrocytesHematomaHumansRatsHemostaticsbehaviorbraincollagenaseserythrocyteshemostasishistology

Identifiers

PMID36069183
PMCPMC9529820
OpenAlexW4294868129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.