Evidence map›Paper›PMID 36069144›Full record

ArticleHIV medicine2022

Re-assessing the late HIV diagnosis surveillance definition in the era of increased and frequent testing.

Peter D Kirwan, Sara Croxford, Adamma Aghaizu, Gary Murphy, Jennifer Tosswill, Alison E Brown, Valerie C Delpech

Open access · hybridAbstract read
In one paragraph

Article in HIV medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Multi-country study on the impact of a revised consensus definition of late HIV diagnosis, Europe, 2022 to 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
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  6. Likelihood of HIV and recent bacterial sexually transmitted infections among transgender and non-binary individuals in 20 European countries, October 2023 to April 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Peter D KirwanUnited Kingdom Health Security Agency, London, UK.ORCID 0000-0001-6904-0500
Sara CroxfordUnited Kingdom Health Security Agency, London, UK.ORCID 0000-0003-2220-623X
Adamma AghaizuUnited Kingdom Health Security Agency, London, UK.ORCID 0000-0003-2857-9168
Gary MurphyUnited Kingdom Health Security Agency, London, UK.ORCID 0000-0002-6331-255X
Jennifer TosswillUnited Kingdom Health Security Agency, London, UK.
Alison E BrownUnited Kingdom Health Security Agency, London, UK.ORCID 0000-0002-6490-6739
Valerie C DelpechUnited Kingdom Health Security Agency, London, UK.ORCID 0000-0002-9952-8109
National Security Agency · US

Funding

Medical Research Council MC_UU_00002/11
6 · The paper itself

Abstract

objectivesLate HIV diagnosis (CD4 <350 cells/mm

methodsWe used national epidemiological and laboratory surveillance data from all people diagnosed with HIV in England, Wales, and Northern Ireland (EW&NI). Those with a baseline CD4 <350 were reclassified as 'not late' if they had evidence of recent infection (recency test and/or negative test within 24 months). A correction factor (CF) was the number reclassified divided by the number with a CD4 <350.

resultsOf the 32 227 people diagnosed with HIV in EW&NI between 2011 and 2019 with a baseline CD4 (81% of total), 46% had a CD4 <350 (uncorrected late diagnosis rate): 34% of gay and bisexual men (GBM), 65% of heterosexual men, and 56% of heterosexual women. Accounting for recency test and/or prior negative tests gave a 'corrected' late diagnosis rate of 39% and corresponding CF of 14%. The CF increased from 10% to 18% during 2011-2015, then plateaued, and was larger among GBM (25%) than heterosexual men and women (6% and 7%, respectively). One-year mortality among people diagnosed late was 329 per 10 000 after reclassification (an increase from 288/10 000).

conclusionsThe case-surveillance definition of late diagnosis increasingly overestimates late presentation, the extent of which differs by key populations. Adjustment of late diagnosis is recommended, particularly for frequent testers such as GBM.

Indexed as

HIV InfectionsSexual and Gender MinoritiesCD4 Lymphocyte CountDelayed DiagnosisFemaleHeterosexualityHumansMaleRisk FactorsHIVHIV testinglate diagnosislate presentationseroconversion

Identifiers

PMID36069144
PMCPMC7613879
OpenAlexW4294916273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.