Evidence map›Paper›PMID 36069030›Full record

ArticleEMBO molecular medicine2022

Neuropilin-1 (NRP1) expression distinguishes self-reactive helper T cells in systemic autoimmune disease.

Ben Je Raveney, Yosif El-Darawish, Wakiro Sato, Yoshiyuki Arinuma, Kunihiro Yamaoka, Shohei Hori, Takashi Yamamura, Shinji Oki

Open access · goldAbstract read
In one paragraph

Article in EMBO molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ben Je RaveneyDepartment of Immunology, National Institute of Neuroscience, Tokyo, Japan.ORCID 0000-0003-2641-5733
Yosif El-DarawishDepartment of Immunology, National Institute of Neuroscience, Tokyo, Japan.ORCID 0000-0002-3257-0740
Wakiro SatoDepartment of Immunology, National Institute of Neuroscience, Tokyo, Japan.ORCID 0000-0003-4082-3557
Yoshiyuki ArinumaDepartment of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan.ORCID 0000-0003-1305-991X
Kunihiro YamaokaDepartment of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan.ORCID 0000-0001-8858-9435
Shohei HoriLaboratory for Immunology and Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-8770-4593
Takashi YamamuraDepartment of Immunology, National Institute of Neuroscience, Tokyo, Japan.ORCID 0000-0001-9048-0375
Shinji OkiDepartment of Immunology, National Institute of Neuroscience, Tokyo, Japan.ORCID 0000-0002-9007-0701
National Center of Neurology and Psychiatry · JPKitasato University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic T helper cells (Th cells) that respond to self-antigen cannot be easily distinguished from beneficial Th cells. These cells can generate systemic autoimmune disease in response to widely expressed self-antigens. In this study, we have identified neuropilin-1 (NRP1) as a cell surface marker of self-reactive Th cells. NRP1

Indexed as

Autoimmune DiseasesNeuropilin-1AnimalsAutoantigensHumansMiceT-Lymphocytes, Helper-InducerAutoantigensNeuropilin-1NRP1 protein, humanneuropilin-1NR4A2self-reactive T helper cellsSLEsystemic autoimmune disease

Identifiers

PMID36069030
PMCPMC9549730
OpenAlexW4294861005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.