Evidence map›Paper›PMID 36068993›Full record

SynthesisBrain and behavior2022

Understanding the association between adverse childhood experiences and subsequent attention deficit hyperactivity disorder: A systematic review and meta-analysis of observational studies.

Ning Zhang, Man Gao, Jinglong Yu, Qiang Zhang, Weiguang Wang, Congxiao Zhou, Lingjia Liu, Ting Sun, Xing Liao, Junhong Wang

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  19. A role for adverse childhood experiences and depression in preeclampsia.Journal of clinical and translational science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ning ZhangDepartment of Pediatrics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Man GaoInstitute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Jinglong YuDepartment of Pediatrics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Qiang ZhangDepartment of Pediatrics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Weiguang WangSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Congxiao ZhouDepartment of Pediatrics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Lingjia LiuDepartment of Pediatrics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Ting SunDepartment of Pediatrics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Xing LiaoCenter of Evidence Based Traditional Chinese Medicine, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Junhong WangDepartment of Pediatrics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAttention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood, which may be related to adverse childhood experiences (ACEs). Our study aims to explore the association between ACEs and subsequent ADHD, and analyze the potential moderators.

methodsLiterature search was conducted by a combined computer-assisted and manual method. Studies were included if they had reported the association between ACEs and subsequent ADHD. Overall estimates of odds ratios (ORs) were obtained using random-effects meta-analyses, meta-regressions and further stratified analyses were conducted to examine potential moderator variables.

resultsTotals of 70 studies involving nearly 4 million participants from among 6,452 unique articles were included. In the primary analyses, ACEs were found to be associated with subsequent ADHD (OR = 1.68, 95% CI: 1.54-1.83), and the negative effects of different forms of ACEs for ADHD were nonequivalent. Such as lived in the stepfamily, been adopted or fostered, and experienced sexual abuse were more deleterious than others. It was found that individuals who had experienced multiple ACEs or who are female were more vulnerable to ADHD.

conclusionsThe findings provide critical evidence for understanding the association between ACEs and ADHD. ACEs could increase the susceptibility of ADHD, especially for individuals who ever experienced multiple ACEs and females.

Indexed as

Adverse Childhood ExperiencesAttention Deficit Disorder with HyperactivityFamilyFemaleHumansMaleOdds Ratioadverse childhood experiencesattention deficit hyperactivity disordermeta-analysissystematic review

Identifiers

PMID36068993
PMCPMC9575611

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.