Evidence map›Paper›PMID 36068986›Full record

ArticleJournal of cachexia, sarcopenia and muscle2022

Impact of body composition and genotype on haemodynamics during surgery for pheochromocytoma and paraganglioma.

Yingxian Pang, Minghao Li, Jingjing Jiang, Xiang Chen, Yan Fu, Cikui Wang, Yao He, Yuanzhe Zhao, Yong Wang, Xiao Guan and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 5 institutions in 4 countries.

Yingxian PangDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Minghao LiDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Jingjing JiangDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Xiang ChenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Yan FuDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Cikui WangDepartment of Urology, Hubei Armed Police Corps Hospital, Wuchang, P. R. China.
Yao HeDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Yuanzhe ZhaoDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Yong WangDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Xiao GuanDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Liang ZhangDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Xiaowen XuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Yu GanDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Yalin LiuXiangya School of Medicine, Central South University, Changsha, Hunan, P. R. China.
Yaoling XieDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Tingyuan TangDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Jing WangDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Bin XieDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Zhihao LiangDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Danlei ChenDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Haipeng LiuDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Changyong ChenDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
Graeme EisenhoferDepartment of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Longfei LiuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.ORCID 0000-0003-0274-4057
Xiaoping YiNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.ORCID 0000-0002-4220-1981
Bihong T ChenDepartment of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, USA.
Central South University · CNCity Of Hope National Medical Center · USFudan University · CNJiangSu Armed Police General Hospital · CNUniversity Hospital Carl Gustav Carus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaintaining intraoperative haemodynamic stability can reduce cardiovascular complications during surgery for pheochromocytoma and paraganglioma (PPGL). Risk factors such as tumour size and catecholamine levels are reported to predict haemodynamic responses during surgery for PPGL. We hypothesized that additional factors including body composition and genetic information could further improve prediction.

methodsConsecutive patients with PPGL confirmed by surgical pathology between June 2010 and June 2019 were retrospectively included. Cross-sectional computed tomography images at the L3 level were used to assess body composition parameters including skeletal muscle area and visceral fat area. Next-generation sequencing was performed using a panel containing susceptibility genes of PPGL. Differences in clinical-genetic characteristics and body composition parameters were analysed and compared in patients with and without intraoperative haemodynamic instability (HDI).

resultsWe included 221 patients with PPGL (median age 47 [38-56] years, and 52% male). Among them, 49.8% had Cluster 2 mutations (related to kinase signalling pathways), 44.8% had sarcopenia, and 52.9% experienced intraoperative HDI. Compared with patients without HDI, more patients with HDI had Cluster 2 mutations (59.8% vs. 38.5%, P = 0.002) and less had sarcopenia (35.9% vs. 54.8%, P = 0.005). Multivariate analysis showed that urine vanillylmandelic acid ≥ 58 μmol/day (adjusted odds ratio [OR] = 1.840, 95% confidence interval [CI] = 1.012-3.347, P = 0.046), tumour size ≥ 4 cm (adjusted OR = 2.278, 95% CI = 1.242-4.180, P = 0.008), and Cluster 2 mutations (adjusted OR = 2.199, 95% CI = 1.128-4.285, P = 0.021) were independent risk factors for intraoperative HDI, while sarcopenia (adjusted OR = 0.475, 95% CI = 0.266-0.846, P = 0.012) decreased the risk.

conclusionsBody composition and genotype were associated with intraoperative haemodynamics in patients with PPGL. Our results indicated that inclusion of body composition and genotype in the overall assessment of patients with PPGL helped to predict HDI during surgery, which could assist in implementing preoperative and intraoperative measures to reduce perioperative complications.

Indexed as

Adrenal Gland NeoplasmsParagangliomaPheochromocytomaBody CompositionCross-Sectional StudiesFemaleHumansMaleMiddle AgedRetrospective StudiesGene mutationsHaemodynamic instabilityParagangliomaPheochromocytomaRisk factorsSarcopenia

Identifiers

PMID36068986
PMCPMC9745493
OpenAlexW4294921090

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.