Evidence map›Paper›PMID 36068685›Full record

ReviewInternational forum of allergy & rhinology2023

International Consensus Statement on Obstructive Sleep Apnea.

Jolie L Chang, Andrew N Goldberg, Jeremiah A Alt, Alzoubaidi Mohammed, Liza Ashbrook, Dennis Auckley, Indu Ayappa, Hira Bakhtiar, José E Barrera, Bethany L Bartley and 130 more

Open access · bronzeAbstract readReviewConsensus Statement
In one paragraph

Review in International forum of allergy & rhinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 196 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 13 pooled it
29.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 13 syntheses or guidelines pooled it, 286 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Maximizing outcomes by multimodal treatment in obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Effect of norepinephrine reuptake inhibitors combined with antimuscarinic agents vs monotherapy for OSA: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Pooled it
  12. Pooled it
  13. Pooled it
  14. Association of tirzepatide with changes in OSA-related measures based on baseline characteristics - post hoc analyses of SURMOUNT-OSA.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Trial
  15. Trial
  16. Trial
  17. Polysomnographic phenotypes: predictors of treatment response in Obstructive Sleep Apnea with Mandibular Advancement devices.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Trial
  18. Article
  19. Article
  20. Rapid eye movement-related obstructive sleep apnea: a physiological phenotype predicting favorable outcomes following palatal surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article

136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

140 authors at 20 institutions in 12 countries.

Jolie L ChangUniversity of California, San Francisco, California, USA.ORCID 0000-0002-0778-1044
Andrew N GoldbergUniversity of California, San Francisco, California, USA.ORCID 0000-0002-0301-2926
Jeremiah A AltUniversity of Utah, Salt Lake City, Utah, USA.ORCID 0000-0003-0560-5028
Alzoubaidi MohammedNorthwestern University, Chicago, Illinois, USA.ORCID 0000-0002-3938-6671
Liza AshbrookUniversity of California, San Francisco, California, USA.ORCID 0000-0003-2437-8203
Dennis AuckleyCase Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0001-9668-7430
Indu AyappaIcahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-8027-9467
Hira BakhtiarNorwalk Hospital, Norwalk, Connecticut, USA.
José E BarreraUniformed Services University, Washington D.C., USA.
Bethany L BartleyHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9043-6697
Martha E BillingsUniversity of Washington, Seattle, Washington, USA.
Maurits S BoonSidney Kimmel Medical Center at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Pien BosschieterAcademic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands.
Itzhak BravermanHillel Yaffe Medical Center, Hadera Technion, Faculty of Medicine, Hadera, Israel.ORCID 0000-0002-1866-9488
Kara BrodieUniversity of California, San Francisco, California, USA.
Cristina Cabrera-MufflyUniversity of Colorado School of Medicine, Aurora, Colorado, USA.
Ray CaesarStone Oak Orthodontics, San Antonio, Texas, USA.
Michel B CahaliUniversity of Sao Paulo, São Paulo, Brazil.ORCID 0000-0002-5704-160X
Yi CaiUniversity of California, San Francisco, California, USA.ORCID 0000-0002-0853-2779
Michelle CaoStanford University, Palo Alto, California, USA.
Robson CapassoStanford University, Palo Alto, California, USA.
Sean M CaplesMayo Clinic, Rochester, Minnesota, USA.
Lana M ChahineUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Corissa P ChangUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Katherine W ChangWashington University, St. Louis, Missouri, USA.
Nilika ChaudharyBrigham and Women's Hospital, Boston, MA, USA.
Crystal S J CheongNational University Hospital, Singapore.ORCID 0000-0002-7238-327X
Susmita ChowdhuriWayne State University and John D. Dingell VA Medical Center, Detroit, Michigan, USA.ORCID 0000-0002-5927-1169
Peter A CistulliFaculty of Medicine and Health, University of Sydney, Sydney, Australia.ORCID 0000-0002-7920-4924
David ClamanUniversity of California, San Francisco, California, USA.
Jacob CollenUniformed Services University, Bethesda, Maryland, USA.
Kevin C CoughlinUniversity of Tennessee, Memphis, Tennessee, USA.
Jennifer CreamerUniformed Services University, Bethesda, Maryland, USA.ORCID 0000-0001-6451-0913
Eric M DavisUniversity of Virginia, Charlottesville, Virginia, USA.
Kara L Dupuy-McCauleyMayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-1874-7818
Megan L DurrKaiser Permanente, Oakland, California, USA.ORCID 0000-0003-1084-8702
Mohan DuttUniversity of Michigan, Ann Arbor, Michigan, USA.
Mazen El AliUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nabil M ElkassabanyUniversity of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0003-3503-4828
Lawrence J EpsteinHarvard Medical School, Boston, Massachusetts, USA.
Justin A FialaNorthwestern University, Chicago, Illinois, USA.ORCID 0000-0001-5196-7076
Neil FreedmanUniversity of Chicago, Chicago, Illinois, USA.
Kirat GillStanford University, Palo Alto, California, USA.
M Boyd GillespieUniversity of Tennessee, Memphis, Tennessee, USA.
Lea GolischUniversity Hospital Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
Nalaka GooneratneUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Daniel J GottliebHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-8812-8751
Katherine K GreenUniversity of Colorado, Aurora, Colorado, USA.
Arushi GulatiUniversity of California, San Francisco, California, USA.ORCID 0000-0002-8060-2954
Indira GurubhagavatulaUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nathan HaywardMonash Health, Victoria, Australia.
Paul T HoffUniversity of Michigan, Ann Arbor, Michigan, USA.
Oliver M G HoffmannUniversity Hospital Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.
Steven J HolfingerOhio State University, Columbus, Ohio, USA.ORCID 0000-0002-2851-9504
Jennifer HsiaUniversity of Minnesota, Minneapolis, Minnesota, USA.
Colin HuntleySidney Kimmel Medical Center at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4637-3630
Kevin C HuohUniversity of California, Irvine, California, USA.
Phillip HuyettHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-1951-3266
Sanjana InalaIcahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-9733-516X
Stacey L IshmanUniversity of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0003-0997-9692
Tarun K JellaCase Western Reserve University, Cleveland, Ohio, USA.
Aesha M JobanputraRutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.ORCID 0000-0002-8293-5971
Andrew P JohnsonUniversity of Colorado School of Medicine, Aurora, Colorado, USA.
Mithri R JunnaMayo Clinic, Rochester, Minnesota, USA.
Jenna T KadoUniversity of Toledo, Toledo, Ohio, USA.ORCID 0000-0002-5214-0115
Thomas M KaffenbergerUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Vishesh K KapurUniversity of Washington, Seattle, Washington, USA.
Eric J KezirianUniversity of Southern California, Los Angeles, California, USA.ORCID 0000-0003-3808-4521
Meena KhanOhio State University, Columbus, Ohio, USA.
Douglas B KirschUniversity of North Carolina School of Medicine, Charlotte.ORCID 0000-0002-8462-8174
Alan KominskyCleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA.
Meir KrygerYale School of Medicine, New Haven, Connecticut, USA.
Andrew D KrystalUniversity of California, San Francisco, California, USA.
Clete A KushidaStanford University, Palo Alto, California, USA.ORCID 0000-0002-9430-3752
Thomas J KuzniarUniversity of Chicago, Chicago, Illinois, USA.
Derek J LamOregon Health and Science University, Portland, Oregon, USA.ORCID 0000-0002-8979-3478
Christopher J LettieriUniformed Services University, Bethesda, Maryland, USA.ORCID 0000-0001-7950-2908
Diane C LimUniversity of Miami, Miami, Florida, USA.
Hsin-Ching LinChang Gung University, Kaohsiung, Taiwan.ORCID 0000-0002-8822-0619
Stanley Y C LiuStanford University, Palo Alto, California, USA.
Stuart G MacKayUniversity of Wollongong, Wollongong, Australia.
Ulysses J MagalangOhio State University, Columbus, Ohio, USA.ORCID 0000-0002-5052-2494
Atul MalhotraUniversity of California, San Diego, California, USA.ORCID 0000-0002-9509-1827
Meghna P MansukhaniMayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-2351-5640
Joachim T MaurerUniversity Hospital Mannheim, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.ORCID 0000-0003-2308-7041
Anna M MayCase Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0002-0181-0086
Ron B MitchellUniversity of Texas, Southwestern and Children's Medical Center Dallas, Texas, USA.ORCID 0000-0001-7890-0541
Babak MokhlesiRush University Medical Center, Chicago, IL, USA.
Anna E MullinsUniversity of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-5143-6977
Eman M NadaStony Brook University, New York, New York, USA.ORCID 0000-0002-0117-9108
Sreelatha NaikGeisinger Health System, Danville, California, USA.ORCID 0000-0002-7183-3435
Brandon NokesUniversity of California, San Diego, California, USA.ORCID 0000-0003-3515-7545
Michael D OlsonMayo Clinic, Rochester, Minnesota, USA.
Allan I PackUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-2879-0484
Edward B PangUniversity of Glasgow, Glasgow, UK.
Kenny P PangParagon Medical Centre, Singapore.
Susheel P PatilCase Western Reserve University, Cleveland, Ohio, USA.
Eli Van de PerckUniversity of Antwerp, Belgium.
Jay F PiccirilloWashington University, St. Louis, Missouri, USA.
Grace W PienJohns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-3228-1612
Amanda J PiperUniversity of Sydney, Sydney, Australia.ORCID 0000-0003-3824-6172
Andrea PlaweckiHenry Ford Health, Detroit, Michigan, USA.
Mark QuiggUniversity of Virginia, Charlottesville, Virginia, USA.
Madeline J L RaveslootOLVG, Amsterdam, The Netherlands.ORCID 0000-0001-5645-5811
Susan RedlineBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-6585-1610
Brian W RotenbergWestern University, Ontario, Canada.ORCID 0000-0003-0258-3142
Armand RydenVeterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Kathleen F SarmientoUniversity of California, San Francisco, California, USA.ORCID 0000-0002-5162-9808
Firas SbeihCleveland Clinic Head and Neck Institute, Cleveland, Ohio, USA.
Amy E SchellUniversity of Colorado, Aurora, Colorado, USA.
Christopher N SchmicklUniversity of California, San Diego, California, USA.ORCID 0000-0001-5417-9980
Helena M SchotlandIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Richard J SchwabUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jiyeon SeoUniversity of California, Los Angeles, California, USA.
Neomi ShahIcahn School of Medicine at Mount Sinai, New York, New York, USA.
Anita Valanju ShelgikarUniversity of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-3629-0084
Isaac ShochatHillel Yaffe Medical Center, Hadera, Israel.ORCID 0000-0003-0153-8956
Ryan J SooseUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-5200-1505
Toby O SteeleUniversity of California, Davis, California, USA.ORCID 0000-0003-4664-6774
Erika StephensUniversity of California, San Francisco, California, USA.ORCID 0000-0002-1272-9208
Carl StepnowskyUniversity of California, San Diego, California, USA.
Kingman P StrohlCase Western Reserve University, Cleveland, Ohio, USA.ORCID 0000-0001-7740-9013
Kate SutherlandUniversity of Sydney, Sydney, Australia.
Maria V SuurnaWeill Cornell Medicine, New York, New York, USA.ORCID 0000-0002-7032-0902
Erica ThalerUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sritika ThapaYale School of Medicine, New Haven, Connecticut, USA.
Olivier M VandervekenUniversity of Antwerp, Belgium.ORCID 0000-0002-4088-4213
Nico de VriesAcademic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands.
Edward M WeaverUniversity of Washington, Seattle, Washington, USA.
Ian D WeirYale School of Medicine, New Haven, Connecticut, USA.
Lisa F WolfeNorthwestern University, Chicago, Illinois, USA.
B Tucker WoodsonMedical College of Wisconsin, Milwaukee, Wisconsin, USA.
Christine H J WonYale School of Medicine, New Haven, Connecticut, USA.
Josie XuUniversity of Toronto, Ontario, Canada.
Pratyusha YalamanchiUniversity of Michigan, Ann Arbor, Michigan, USA.
Kathleen YaremchukHenry Ford Health, Detroit, Michigan, USA.
Yerem YeghiazariansUniversity of California, San Francisco, California, USA.
Jason L YuEmory University, Georgia, USA.ORCID 0000-0001-8009-5000
Michelle ZeidlerUniversity of California, Los Angeles, California, USA.
Ilene M RosenUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-8263-8600
University of California, San Francisco · USUniversity of Pennsylvania · USCase Western Reserve University · USMayo Clinic · USPalo Alto University · USHarvard University · USIcahn School of Medicine at Mount Sinai · USUniversity of California San Diego · USUniversity of Michigan · USUniversity of Pittsburgh · USYale University · USHeidelberg University · DENorthwestern University · USThe Ohio State University · USThe University of Sydney · AUUniformed Services University of the Health Sciences · USUniversity of Chicago · USUniversity of Virginia · USUniversity of Washington · USAcademic Center for Dentistry Amsterdam · NL

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Institutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1M
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
Developing a Diverse Next Generation of Leaders in Respiratory ScienceT32HL166127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Laura Elise Crotty Alexander, Atul Malhotra · 2023 to 2026
$1.6M
Acetazolamide to Improve Clinically Important Outcomes in Obstructive Sleep Apnea Patients with a High Loop Gain EndotypeK23HL161336 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christopher Nikolaus Schmickl · 2022 to 2026
$863k
Assessment of Upper Airway Mechanics Using Newer Electromyographic TechniquesK24HL132105 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2016 to 2020
$611k
CSRD VA IK2 CX001882NCATS NIH HHS KL2 TR002381NCATS NIH HHS UL1 TR001863NCATS NIH HHS UL1 TR002378NHLBI NIH HHS K23 HL161336NHLBI NIH HHS K24 HL132105NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS T32 HL134632NHLBI NIH HHS T32 HL166127NIA NIH HHS R01 AG063925NIA NIH HHS U54 AG062334
6 · The paper itself

Abstract

backgroundEvaluation and interpretation of the literature on obstructive sleep apnea (OSA) allows for consolidation and determination of the key factors important for clinical management of the adult OSA patient. Toward this goal, an international collaborative of multidisciplinary experts in sleep apnea evaluation and treatment have produced the International Consensus statement on Obstructive Sleep Apnea (ICS:OSA).

methodsUsing previously defined methodology, focal topics in OSA were assigned as literature review (LR), evidence-based review (EBR), or evidence-based review with recommendations (EBR-R) formats. Each topic incorporated the available and relevant evidence which was summarized and graded on study quality. Each topic and section underwent iterative review and the ICS:OSA was created and reviewed by all authors for consensus.

resultsThe ICS:OSA addresses OSA syndrome definitions, pathophysiology, epidemiology, risk factors for disease, screening methods, diagnostic testing types, multiple treatment modalities, and effects of OSA treatment on multiple OSA-associated comorbidities. Specific focus on outcomes with positive airway pressure (PAP) and surgical treatments were evaluated.

conclusionThis review of the literature consolidates the available knowledge and identifies the limitations of the current evidence on OSA. This effort aims to create a resource for OSA evidence-based practice and identify future research needs. Knowledge gaps and research opportunities include improving the metrics of OSA disease, determining the optimal OSA screening paradigms, developing strategies for PAP adherence and longitudinal care, enhancing selection of PAP alternatives and surgery, understanding health risk outcomes, and translating evidence into individualized approaches to therapy.

Indexed as

Sleep Apnea, ObstructiveAdultContinuous Positive Airway PressureHumansPolysomnographyRisk Factorsatrial fibrillationcardiovascular eventcerebrovascular diseaseconsensusdementiaevidence-based medicinehome sleep apnea testinghypertensionhypoglossal nerve stimulationmortalitymotor vehicle accidentsneurocognitive functionobstructive sleep apneaoutcomesPAP adherenceperioperative managementpolysomnographypositive airway pressurescreeningsleepsleep disordered breathingsleepinesssleep surgerysurgical outcomessystematic reviewtreatment outcomesuvulopalatopharyngoplasty

Identifiers

PMID36068685
PMCPMC10359192
OpenAlexW4294921050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.