Evidence map›Paper›PMID 36068676›Full record

ArticleBritish journal of pharmacology2022

Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea.

Raj Makwana, Ellie Crawley, Marilisa Straface, Alexandra Palmer, Armen Gharibans, Kalpana Devalia, John Loy, Greg O'Grady, Paul L R Andrews, Gareth J Sanger

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Sensory signals for nausea.Trends in neurosciences · 2025
    Review
  3. The psychedelic-peptide paradox: a hormetic hypothesis.Comprehensive psychoneuroendocrinology · 2025
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Raj MakwanaBlizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0003-2175-3530
Ellie CrawleyBlizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Marilisa StrafaceBlizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Alexandra PalmerBlizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Armen GharibansDepartment of Surgery and Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Kalpana DevaliaBariatric Surgery Department, Homerton University Hospital, London, UK.
John LoyBariatric Surgery Department, Homerton University Hospital, London, UK.
Greg O'GradyDepartment of Surgery and Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Paul L R AndrewsDivision of Biomedical Sciences, St George's University of London, London, UK.ORCID 0000-0001-7099-6964
Gareth J SangerBlizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-4231-1945
Queen Mary University of London · GBAuckland Institute of Studies · NZHomerton University Hospital · GBSt George's, University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeNausea is associated with the hormonal secretion of vasopressin and adrenaline, although their actions in inducing nausea is poorly understood. Here, we have investigated their actions on human stomach muscle. EXPERIMENTAL APPROACH: Muscle strips were suspended in tissue baths and neuronal-/non-neuronally-mediated contractions were measured. Custom software analysed eight motility parameters defining spontaneous phasic non-neuronally mediated contractions. Receptor distributions were assessed by qPCR and immunofluorescence. KEY

resultsV CONCLUSIONS AND IMPLICATIONS: Vasopressin and adrenaline increased human gastric tone and myogenic contraction amplitude, rate of contraction and frequency. In combination, their actions were further increased in a synergistic manner. Such activity may promote nausea.

Indexed as

Arginine VasopressinEpinephrineHumansMuscle ContractionNauseaReceptors, Adrenergic, betaStomachVasopressinsArginine VasopressinEpinephrineReceptors, Adrenergic, betaVasopressinsadrenalinearginine vasopressinhumaninterstitial cells of Cajalnauseastomach

Identifiers

PMID36068676
PMCPMC9826163
OpenAlexW4294921110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.