Evidence map›Paper›PMID 36068619›Full record

ReviewCancer imaging : the official publication of the International Cancer Imaging Society2022

The current status and future prospects for molecular imaging-guided precision surgery.

Imke Boekestijn, Matthias N van Oosterom, Paolo Dell'Oglio, Floris H P van Velden, Martin Pool, Tobias Maurer, Daphne D D Rietbergen, Tessa Buckle, Fijs W B van Leeuwen

Abstract readReview
In one paragraph

Review in Cancer imaging : the official publication of the International Cancer Imaging Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Nuclear medicine in the operating room: present and future.The British journal of radiology · 2026
    Review
  4. Review
  5. Translation of Intraoperative Molecular Imaging for Clinical Use.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. A Minimally Invasive Robotic Tissue Palpation Device.IEEE transactions on bio-medical engineering · 2024
    Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Imke BoekestijnInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Matthias N van OosteromInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Paolo Dell'OglioInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Floris H P van VeldenMedical Physics, Department of Radiology , Leiden University Medical Center, Leiden, the Netherlands.
Martin PoolDepartment of Clinical Farmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands.
Tobias MaurerMartini-Klinik Prostate Cancer Centre Hamburg, Hamburg, Germany.
Daphne D D RietbergenInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Tessa BuckleInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
Fijs W B van LeeuwenInterventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. f.w.b.van_leeuwen@lumc.nl.ORCID http://orcid.org/0000-0002-6844-4025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular imaging technologies are increasingly used to diagnose, monitor, and guide treatment of i.e., cancer. In this review, the current status and future prospects of the use of molecular imaging as an instrument to help realize precision surgery is addressed with focus on the main components that form the conceptual basis of intraoperative molecular imaging. Paramount for successful interventions is the relevance and accessibility of surgical targets. In addition, selection of the correct combination of imaging agents and modalities is critical to visualize both microscopic and bulk disease sites with high affinity and specificity. In this context developments within engineering/imaging physics continue to drive the growth of image-guided surgery. Particularly important herein is enhancement of sensitivity through improved contrast and spatial resolution, features that are critical if sites of cancer involvement are not to be overlooked during surgery. By facilitating the connection between surgical planning and surgical execution, digital surgery technologies such as computer-aided visualization nicely complement these technologies. The complexity of image guidance, combined with the plurality of technologies that are becoming available, also drives the need for evaluation mechanisms that can objectively score the impact that technologies exert on the performance of healthcare professionals and outcome improvement for patients.

Indexed as

NeoplasmsSurgery, Computer-AssistedHumansMolecular ImagingDigital surgeryFluorescence imagingImage-guided therapyIntraoperative molecular imagingMultimodal imagingPharmacokineticsSurgerySurgical navigation

Identifiers

PMID36068619
PMCPMC9446692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.