ArticleBMC pharmacology & toxicology2022
Prediction of mortality and morbidity following paraquat poisoning based on trend of liver and kidney injury.
Article in BMC pharmacology & toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 25 citations in OpenAlex.
- Complete pulmonary and renal recovery following severe paraquat poisoning: a six‑month radiological follow‑up and dynamic hematological observation.International journal of emergency medicine · 2026Article
- Clinical epidemiology and outcome of paraquat poisoning - A 12-year patient record based observational study.Journal of family medicine and primary care · 2026Article
- Prediction of acute kidney injury in patients with acute pesticide poisoning using the PKIP score.Scientific reports · 2026Article
- Clinical characteristics and early admission predictors of in-hospital death in acute paraquat poisoning: a retrospective cohort study of 128 patients.Frontiers in medicine · 2026Article
- A Prospective Study to Assess the Profile and Outcome of Acute Paraquat Poisoning in a Tertiary Care Hospital of West Bengal.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Comparison of oxidative stress status in the kidney tissue of male rats treated with paraquat and nanoparaquat.Scientific reports · 2025Article
- Utility of Clinical Variables for Deciding Palliative Care in Paraquat Poisoning: A Retrospective Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Development and validation of a prognostic nomogram for predicting in-hospital mortality of patients with acute paraquat poisoning.Scientific reports · 2024Observational
- Epidemiology and Management of Drug-induced Liver Injury: Importance of the Updated RUCAM.Journal of clinical and translational hepatology · 2023Review
- Predicting mortality in paraquat poisoning through clinical findings, with a focus on pulmonary and cardiovascular system disorders.Journal of pharmaceutical policy and practice · 2023Article
- Effects of early repeated hemoperfusion combined with hemodialysis on the prognosis of patients with paraquat poisoning.American journal of translational research · 2023Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParaquat is a non-selective herbicide that causes severe tissue damage in various organs including the liver and kidney. The aim of this study was to determine the trend of the liver and kidney injury in patients with paraquat poisoning.
methodsThis retrospective cross-sectional study was performed at the Khorshid Hospital referral poisoning emergency center. The medical records of all patients with acute paraquat poisoning admitted from March 2017 to October 2020 were reviewed. Demographic factors, liver and kidney function tests and outcomes were recorded. Patients were divided into two groups based on the outcome of mortality (death or survived). The two groups were compared in terms of changes in creatinine and liver enzymes during hospitalization.
resultsA significant difference in mean creatinine levels between the two groups was observed from the third day after admission. The peak median Cr was 3.5 mg/dl for deceased patients in day 6 and 1.47 mg/dl for survived patients on 4th day. Minor elevations of ALT and AST were present in those who died. Logistic regression analysis shows patients who had level of creatinine higher than normal from the 2nd to 6th day post overdose, the risk of mortality was 4.83 to 7.44 times more than patients with normal creatinine level. The mean (SD) area under the curve for outcome prediction was reported to be excellent for creatinine on the 8th day post overdose (85.7 ± 13.2). Creatinine was higher than 2 on the 8th day post ingestion and had a sensitivity 100% and specificity 85.7% for mortality prediction (P value, 0.05).
conclusionsThe risk of mortality secondary to paraquat ingestion was highly associated with a rise in creatinine. Minor elevations of ALT and AST were also present in those who died. The creatinine concentration on different days post overdose can be helpful in predicting the severity of poisoning especially when the serum paraquat levels are not available.
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