Evidence map›Paper›PMID 36068429›Full record

ArticleNeurology and therapy2022

Expert-Agreed Practical Recommendations on the Use of Cladribine.

Virginia Meca-Lallana, José M García Domínguez, Rocío López Ruiz, Jesús Martín-Martínez, Adrián Arés Luque, Miguel A Hernández Pérez, José M Prieto González, Lamberto Landete Pascual, Jaume Sastre-Garriga

Abstract read
In one paragraph

Article in Neurology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
  6. Identifying Cladribine prescription pattern in MS: an Italian multicentre study.Therapeutic advances in neurological disorders · 2025
    Article
  7. Cladribine tablets in the new multiple sclerosis era.Therapeutic advances in neurological disorders · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Virginia Meca-LallanaMultiple Sclerosis Unit, Department of Neurology, Hospital Universitario "La Princesa", Madrid, Spain. virmeca@hotmail.com.
José M García DomínguezDemyelinating Diseases Unit, Hospital Gregorio Marañón, Madrid, Spain.
Rocío López RuizMultiple Sclerosis Unit, Hospital Universitario Virgen Macarena, Seville, Spain.
Jesús Martín-MartínezDepartment of Neurology, Hospital Universitario Miguel Servet, Saragossa, Spain.
Adrián Arés LuqueNeurology Department, Complejo Asistencial Universitario de León, León, Spain.
Miguel A Hernández PérezHospital Universitario Ntra. Sra de Candelaria, Santa Cruz de Tenerife, Spain.
José M Prieto GonzálezNeurology Unit, Hospital Clínico Universitario, Santiago de Compostela, A Coruña, Spain.
Lamberto Landete PascualNeurology Department, Hospital Universitario Dr. Peset, Valencia, Spain.
Jaume Sastre-GarrigaNeurology Department, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cladribine is a disease-modifying selective immune reconstitution oral therapy for adult patients with highly active relapsing multiple sclerosis (RMS). It was approved in the USA in 2019 and in Europe in 2017, thus there are still gaps in existing guidelines for using cladribine tablets in clinical practice. Nine experts with extensive experience in managing patients with multiple sclerosis in Spain identified some of the unanswered questions related to the real-life use of cladribine tablets. They reviewed the available clinical trial data and real-world evidence, including their own experiences of using cladribine, over the course of three virtual meetings held between November 2020 and January 2021. This article gathers their practical recommendations to aid treatment decision-making and optimise the use of cladribine tablets in patients with RMS. The consensus recommendations cover the following areas: candidate patient profiles, switching strategies (to and from cladribine), managing response to cladribine and safety considerations.

Indexed as

CladribineConsensusDisease-modifying drugsExpert opinionRelapsing multiple sclerosisTreatment response

Identifiers

PMID36068429
PMCPMC9447968

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.