Evidence map›Paper›PMID 36068400›Full record

ArticleMolecular neurobiology2022

Senegenin Rescues PC12 Cells with Oxidative Damage Through Inhibition of Ferroptosis.

Heping Zhang, Wei Zhou, Jianling Li, Zhaohui Qiu, Xiaotong Wang, Hui Xu, Huadong Wang, Daxiang Lu, Renbin Qi

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  4. Article
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  6. Review
  7. Non-canonical cell death in neurodegeneration: emerging mechanisms and therapeutic Frontiers.Apoptosis : an international journal on programmed cell death · 2026
    Review
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  11. Review
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  14. Article
  15. Saponin components inFrontiers in pharmacology · 2024
    Review
  16. Iron and Targeted Iron Therapy in Alzheimer's Disease.International journal of molecular sciences · 2023
    Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Heping Zhang *Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, School of Medicine, Jinan University, No. 601 Avenue Huangpu West, Guangzhou, 510632, Guangdong, China.
Wei Zhou *Department of Internal Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, Guangdong, China.
Jianling Li *Department of Anesthesiology, First Affiliated Hospital of Jinan University, Guangdong, 510630, Guangzhou, China.
Zhaohui Qiu *Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, School of Medicine, Jinan University, No. 601 Avenue Huangpu West, Guangzhou, 510632, Guangdong, China.
Xiaotong WangDepartment of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, School of Medicine, Jinan University, No. 601 Avenue Huangpu West, Guangzhou, 510632, Guangdong, China.
Hui XuDepartment of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, School of Medicine, Jinan University, No. 601 Avenue Huangpu West, Guangzhou, 510632, Guangdong, China.
Huadong WangDepartment of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, School of Medicine, Jinan University, No. 601 Avenue Huangpu West, Guangzhou, 510632, Guangdong, China.
Daxiang LuDepartment of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, School of Medicine, Jinan University, No. 601 Avenue Huangpu West, Guangzhou, 510632, Guangdong, China.
Renbin QiDepartment of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, School of Medicine, Jinan University, No. 601 Avenue Huangpu West, Guangzhou, 510632, Guangdong, China. tqirb@jnu.edu.cn.ORCID http://orcid.org/0000-0002-6475-5993
Jinan University · CNFirst Affiliated Hospital of Jinan University · CNGuangzhou Chest Hospital · CNSun Yat-sen University · CN

Funding

Natural Science Foundation of Guangdong Province for Distinguished Young Scholars No. 2014A030313394Project of Science and Technology Plan in Guangzhou 202201020016the Fundamental Research Funds for the Central Universities in China No. 21613401the Project of Science and Technology of Guangzhou 2014J4100098
6 · The paper itself

Abstract

Oxidative stress is one of the pathological mechanisms of Alzheimer's disease (AD), and ferroptosis has been determined to be involved in neurodegenerative diseases such as AD. Senegenin (Sen) prevents oxidative damage in nerve cells via a mechanism that may be highly related to ferroptosis. However, the mechanism of ferroptosis pathway involvement in AD is unclear. In this study, we established a model of PC12 cytotoxic injury induced by Aβ

Indexed as

Alzheimer DiseaseFerroptosisAmyloid beta-PeptidesAnimalsApoptosisDrugs, Chinese HerbalHumansLipidsOxidative StressPC12 CellsPeptide FragmentsRatsReactive Oxygen SpeciesAmyloid beta-PeptidesDrugs, Chinese HerbalLipidsPeptide FragmentsReactive Oxygen SpeciestenuigeninAlzheimer’s diseaseAβ25–35FerroptosisOxidative stressSenegenin

Identifiers

PMID36068400
OpenAlexW4295015284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.