ArticleCell research2022
A spontaneous thermo-sensitive female sterility mutation in rice enables fully mechanized hybrid breeding.
Article in Cell research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 20 citations in OpenAlex.
- Innovations in hybrid rice seed production: Integrating agronomy, mechanization, and biotechnology.Plant communications · 2026Review
- The tasiR-ARF pathway in plants: origin, functions, and interplay of miR-390, tasiRNAs and ARF3.Plant biology (Stuttgart, Germany) · 2026Review
- Plant microRNA maturation and function.Nature reviews. Molecular cell biology · 2026Review
- Heat stress impact on rice reproductive processes: challenges and new approaches.Frontiers in genome editing · 2026Review
- Cytological and Ploidy Analyses Revealing Fertility Defects of CultivarPlants (Basel, Switzerland) · 2025Article
- Fine mapping of the dominant female sterility gene and novel model of hybrid seed production in cabbage (Brassica oleracea L. var. capitata).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Epigenetics in the modern era of crop improvements.Science China. Life sciences · 2025Review
- A TOPLESS-related gene regulates both male and female sterility in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Insights into lncRNA-mediated regulatory networks in Hevea brasiliensis under anthracnose stress.Plant methods · 2024Article
- How Rice Responds to Temperature Changes and Defeats Heat Stress.Rice (New York, N.Y.) · 2024Review
- Modulation of histone acetylation enables fully mechanized hybrid rice breeding.Nature plants · 2024Article
- Pedigree genome data of an early-matured Geng/japonica glutinous rice mega variety Longgeng 57.Scientific data · 2024Article
- Changes in mBMC plant biology · 2023Article
- CRISPR/Cas Technology Revolutionizes Crop Breeding.Plants (Basel, Switzerland) · 2023Review
- The chromatin accessibility landscape of pistils and anthers in rice.Plant physiology · 2022Review
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male sterility enables hybrid crop breeding to increase yields and has been extensively studied. But thermo-sensitive female sterility, which is an ideal property that may enable full mechanization in hybrid rice breeding, has rarely been investigated due to the absence of such germplasm. Here we identify the spontaneous thermo-sensitive female sterility 1 (tfs1) mutation that confers complete sterility under regular/high temperature and partial fertility under low temperature as a point mutation in ARGONAUTE7 (AGO7). AGO7 associates with miR390 to form an RNA-Induced Silencing Complex (RISC), which triggers the biogenesis of small interfering RNAs (siRNAs) from TRANS-ACTING3 (TAS3) loci by recruiting SUPPRESSOR OF GENE SILENCING (SGS3) and RNA-DEPENDENT RNA POLYMERASE6 (RDR6) to TAS3 transcripts. These siRNAs are known as tasiR-ARFs as they act in trans to repress auxin response factor genes. The mutant TFS1 (mTFS1) protein is compromised in its ability to load the miR390/miR390* duplex and eject miR390* during RISC formation. Furthermore, tasiR-ARF levels are reduced in tfs1 due to the deficiency in RDR6 but not SGS3 recruitment by mTFS1 RISC under regular/high temperature, while low temperature partially restores mTFS1 function in RDR6 recruitment and tasiR-ARF biogenesis. A miR390 mutant also exhibits female sterility, suggesting that female fertility is controlled by the miR390-AGO7 module. Notably, the tfs1 allele introduced into various elite rice cultivars endows thermo-sensitive female sterility. Moreover, field trials confirm the utility of tfs1 as a restorer line in fully mechanized hybrid rice breeding.
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