Evidence map›Paper›PMID 36068285›Full record

ArticleNPJ precision oncology2022

Circulating tumor DNA sequencing provides comprehensive mutation profiling for pediatric central nervous system tumors.

Erin R Bonner, Robin Harrington, Augustine Eze, Miriam Bornhorst, Cassie N Kline, Heather Gordish-Dressman, Adam Dawood, Biswajit Das, Li Chen, Rini Pauly and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Erin R BonnerCenter for Genetic Medicine Research, Children's National Hospital, Washington, DC, USA.
Robin HarringtonMolecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Augustine EzeCenter for Genetic Medicine Research, Children's National Hospital, Washington, DC, USA.
Miriam BornhorstCenter for Genetic Medicine Research, Children's National Hospital, Washington, DC, USA.
Cassie N KlineDivision of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Heather Gordish-DressmanDepartment of Biostatistics, Children's National Hospital, Washington, DC, USA.
Adam DawoodCenter for Genetic Medicine Research, Children's National Hospital, Washington, DC, USA.
Biswajit DasMolecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Li ChenMolecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Rini PaulyMolecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
P Mickey WilliamsMolecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0002-3309-5988
Chris KarlovichMolecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Amanda PeachMolecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
D'andra HowellMolecular Characterization Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
James DoroshowDivision of Cancer Treatment and Diagnosis, Developmental Therapeutics Clinic/Early Clinical Trials Development Program, National Cancer Institute, Bethesda, MD, USA.
Lindsay KilburnBrain Tumor Institute, Children's National Hospital, Washington, DC, USA.
Roger J PackerBrain Tumor Institute, Children's National Hospital, Washington, DC, USA.
Sabine MuellerDepartment of Neurology, Neurosurgery and Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Javad NazarianCenter for Genetic Medicine Research, Children's National Hospital, Washington, DC, USA. jnazarian@childrensnational.org.
Children's National · USFrederick National Laboratory for Cancer Research · USChildren's Hospital of Philadelphia · USNational Cancer Institute · USUniversity of California, San Francisco · US

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Research Training in Childhood CancerT32CA128583 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eric Alejandro Sweet-Cordero · 2007 to 2026
$6.0M
CCR NIH HHS HHSN261200800001CNCATS NIH HHS UL1 TR001876NCI NIH HHS HHSN261200800001ENCI NIH HHS T32 CA128583NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

Molecular profiling of childhood CNS tumors is critical for diagnosis and clinical management, yet tissue access is restricted due to the sensitive tumor location. We developed a targeted deep sequencing platform to detect tumor driver mutations, copy number variations, and heterogeneity in the liquid biome. Here, we present the sensitivity, specificity, and clinical relevance of our minimally invasive platform for tumor mutation profiling in children diagnosed with CNS cancer.

Identifiers

PMID36068285
PMCPMC9448784
OpenAlexW4294843248

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.