ArticleNPJ Parkinson's disease2022
Cerebro-cerebellar motor networks in clinical subtypes of Parkinson's disease.
Article in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive function in different motor subtypes of Parkinson's disease: A systematic review and multilevel meta-analysis.Cognitive, affective & behavioral neuroscience · 2026Pooled it
- Altered brain connectivity in hyperkinetic movement disorders: A review of resting-state fMRI.NeuroImage. Clinical · 2023Pooled it
- Cerebellar transcranial magnetic stimulation improves motor function in Parkinson's disease.Annals of clinical and translational neurology · 2024Trial
- Impulse Control Disorders Are Independent of Parkinson Disease Motor Subtypes.medRxiv : the preprint server for health sciences · 2026Article
- Relationship between excessive daytime sleepiness and motor subtype transition in untreated prodromal Parkinson's disease: a cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Beyond nigrostriatal dopamine transporter loss: whole-brain DAT depletion patterns discriminate PD phenotypes.European journal of nuclear medicine and molecular imaging · 2026Article
- AI-Assisted Self-Powered Wearable Dual-Mode Sensor With TENG and Stretchable Optical Fiber for Neurological Disorder Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- White matter alterations in tremor-dominant and postural instability and gait disturbance subtypes of Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Exploratory radiomics analysis of T1-weighted and FLAIR MRI in relation to Parkinson's disease motor subtypes.Frontiers in neurology · 2026Article
- Volumetric signatures of basal ganglia-thalamo-cortical and cerebello-thalamo-cortical networks in Parkinson's disease and its motor subtypes.Frontiers in aging neuroscience · 2026Article
- Early classification of functional connectomes in Parkinson's disease: a comparison of machine learning classifiers using multi-scale topological features.BMC medical informatics and decision making · 2025Article
- Parkinson's Disease: Bridging Gaps, Building Biomarkers, and Reimagining Clinical Translation.Cells · 2025Review
- Regional-specific structural and functional changes of posterior cerebellar vermis across different stages of Parkinson's disease with gait dysfunction.NPJ Parkinson's disease · 2025Article
- Hot Topics and Frontiers of Resting-State fMRI in Parkinson's Disease: Research Trends and Paradigm Shifts From a Bibliometric Perspective.Parkinson's disease · 2025Review
- Functional remapping in networks of the Parkinsonian brain: A preclinical neuroimaging perspective with clinical correlates.Translational neuroscience · 2025Review
- First steps matter: gait initiation reveals emotion-driven motor compensation in Parkinson's disease.Brain communications · 2025Article
- Stepwise connectivity of the entorhinal cortex along connectomic gradients in Alzheimer's disease.Brain communications · 2025Article
- Cerebellar Structural and N-Acetylaspartate, Choline, and Creatine Metabolic Profiles in Parkinson's Disease and Essential Tremor.Diagnostics (Basel, Switzerland) · 2024Article
- Neural correlates of bradykinesia in Parkinson's disease: a kinematic and functional MRI study.NPJ Parkinson's disease · 2024Article
- Data-Driven Discovery of Movement-Linked Heterogeneity in Neurodegenerative Diseases.Nature machine intelligence · 2024Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Parkinson's disease (PD) patients can be classified in tremor-dominant (TD) and postural-instability-and-gait-disorder (PIGD) motor subtypes. PIGD represents a more aggressive form of the disease that TD patients have a potentiality of converting into. This study investigated functional alterations within the cerebro-cerebellar system in PD-TD and PD-PIGD patients using stepwise functional connectivity (SFC) analysis and identified neuroimaging features that predict TD to PIGD conversion. Thirty-two PD-TD, 26 PD-PIGD patients and 60 healthy controls performed clinical/cognitive evaluations and resting-state functional MRI (fMRI). Four-year clinical follow-up data were available for 28 PD-TD patients, who were classified in 10 converters (cTD-PD) and 18 non-converters (ncTD-PD) to PIGD. The cerebellar seed-region was identified using a fMRI motor task. SFC analysis, characterizing regions that connect brain areas to the cerebellar seed at different levels of link-step distances, evaluated similar and divergent alterations in PD-TD and PD-PIGD. The discriminatory power of clinical data and/or SFC in distinguishing cPD-TD from ncPD-TD patients was assessed using ROC curve analysis. Compared to PD-TD, PD-PIGD patients showed decreased SFC in temporal lobe and occipital lobes and increased SFC in cerebellar cortex and ponto-medullary junction. Considering the subtype-conversion analysis, cPD-TD patients were characterized by increased SFC in temporal and occipital lobes and in cerebellum and ponto-medullary junction relative to ncPD-TD group. Combining clinical and SFC data, ROC curves provided the highest classification power to identify conversion to PIGD. These findings provide novel insights into the pathophysiology underlying different PD motor phenotypes and a potential tool for early characterization of PD-TD patients at risk of conversion to PIGD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.