Evidence map›Paper›PMID 36068236›Full record

ArticleNature communications2022

Genomic surveillance of SARS-CoV-2 Omicron variants on a university campus.

Ana A Weil, Kyle G Luiten, Amanda M Casto, Julia C Bennett, Jessica O'Hanlon, Peter D Han, Luis S Gamboa, Evan McDermot, Melissa Truong, Geoffrey S Gottlieb and 19 more

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  16. Antiviral Drugs and Vaccines for Omicron Variant: A Focused Review.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Review
  17. Article
  18. Evaluating the COVID-19 Containment Protocol in Greek Universities for the Academic Year 2021-2022.International journal of environmental research and public health · 2022
    Article
  19. Global estimates of the fitness advantage of SARS-CoV-2 variant Omicron.medRxiv : the preprint server for health sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Ana A WeilDepartment of Medicine, University of Washington, Seattle, WA, USA. anaweil@uw.edu.ORCID 0000-0002-6170-4306
Kyle G LuitenDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4473-5714
Amanda M CastoDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8332-8578
Julia C BennettDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2559-2922
Jessica O'HanlonDepartment of Medicine, University of Washington, Seattle, WA, USA.
Peter D HanBrotman Baty Institute, Seattle, WA, USA.
Luis S GamboaBrotman Baty Institute, Seattle, WA, USA.
Evan McDermotBrotman Baty Institute, Seattle, WA, USA.
Melissa TruongBrotman Baty Institute, Seattle, WA, USA.
Geoffrey S GottliebDepartment of Medicine, University of Washington, Seattle, WA, USA.
Zack AckerBrotman Baty Institute, Seattle, WA, USA.
Caitlin R WolfDepartment of Medicine, University of Washington, Seattle, WA, USA.
Ariana MagedsonDepartment of Medicine, University of Washington, Seattle, WA, USA.
Eric J ChowDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3349-9330
Natalie K LoDepartment of Medicine, University of Washington, Seattle, WA, USA.
Lincoln C PothanBrotman Baty Institute, Seattle, WA, USA.
Devon McDonaldDepartment of Medicine, University of Washington, Seattle, WA, USA.
Tessa C WrightDepartment of Medicine, University of Washington, Seattle, WA, USA.
Kathryn M McCaffreyBrotman Baty Institute, Seattle, WA, USA.
Marlin D FigginsVaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Janet A EnglundSeattle Children's Research Institute, Department of Pediatrics, University of Washington, Seattle, WA, USA.
Michael BoeckhVaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Christina M LockwoodBrotman Baty Institute, Seattle, WA, USA.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Jay ShendureBrotman Baty Institute, Seattle, WA, USA.ORCID 0000-0002-1516-1865
Trevor BedfordVaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
James P HughesDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Lea M StaritaBrotman Baty Institute, Seattle, WA, USA.
Helen Y ChuDepartment of Medicine, University of Washington, Seattle, WA, USA.

Funding

HOST DEFENSE TRAINING IN ALLERGY AND INFECTIOUS DISEASEST32AI007044 · NIAID · UNIVERSITY OF WASHINGTON · PI DAVID Neal FREDRICKS · 1985 to 2026
$14.6M
NIAID NIH HHS T32 AI007044
6 · The paper itself

Abstract

Novel variants continue to emerge in the SARS-CoV-2 pandemic. University testing programs may provide timely epidemiologic and genomic surveillance data to inform public health responses. We conducted testing from September 2021 to February 2022 in a university population under vaccination and indoor mask mandates. A total of 3,048 of 24,393 individuals tested positive for SARS-CoV-2 by RT-PCR; whole genome sequencing identified 209 Delta and 1,730 Omicron genomes of the 1,939 total sequenced. Compared to Delta, Omicron had a shorter median serial interval between genetically identical, symptomatic infections within households (2 versus 6 days, P = 0.021). Omicron also demonstrated a greater peak reproductive number (2.4 versus 1.8), and a 1.07 (95% confidence interval: 0.58, 1.57; P < 0.0001) higher mean cycle threshold value. Despite near universal vaccination and stringent mitigation measures, Omicron rapidly displaced the Delta variant to become the predominant viral strain and led to a surge in cases in a university population.

Indexed as

COVID-19SARS-CoV-2Genome, ViralGenomicsHumansRNA, ViralUniversitiesRNA, Viral

Identifiers

PMID36068236
PMCPMC9446629

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.