ArticleNature communications2022
Long read genome assemblies complemented by single cell RNA-sequencing reveal genetic and cellular mechanisms underlying the adaptive evolution of yak.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Pooled it
- Association ofAnimals : an open access journal from MDPI · 2026Article
- The Role of Cold Shock Protein (CSP) Gene Family in Yak (Bos grunniens) for High-Altitude Adaptation: Genome-Wide Identification and Analysis.Animal genetics · 2026Article
- Evolutionary convergence and niche-specific regulation of core HIF1A pathway genes synergistically drive divergent hypoxia adaptation in mammals.BMC ecology and evolution · 2026Article
- Genome-wide detection and genomic selection based on genotype-by-environment interaction-associated signals for yak coat color.BMC genomics · 2026Article
- Post-Transcriptional Regulatory Network of Non-Coding RNAs in Yaks: Molecular Mechanisms of Hypoxia Adaptation and Productive Traits.Animals : an open access journal from MDPI · 2026Review
- A comprehensive full-length transcriptome atlas across multiple organs of an Indian yak breed-Arunachali.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Multi-Omics Analysis Reveals New Insights into Yak Lung Under High-Altitude Adaptation.Animals : an open access journal from MDPI · 2026Article
- The price of survival: comparative adaptation to high altitudes between yaks and cattle.Animal microbiome · 2026Article
- Divergent Amplification of Y-Linked Dosage-Sensitive Genes Triggers Regulatory Mismatch Underlying Cattle-Yak Male Sterility.Biomolecules · 2026Article
- The Genomic Landscape of Cattle: Domestication, Dispersal, and Adaptive Evolution.Animals : an open access journal from MDPI · 2026Review
- Mechanism of Dietary Variation of Grazing Yaks on Tibetan Plateau: The Role of Seasonal Heterogeneity of Resources.Ecology and evolution · 2026Article
- Genomic Signatures Underlying Environmental Adaptation and Reproductive Traits in the Tibetan Pig.Animals : an open access journal from MDPI · 2026Article
- Dynamic regulation of spermatogenesis and hybrid sterility revealed by single-cell analysis in yak and cattle.Molecular biology and evolution · 2026Article
- Hypoxia-Driven Pulmonary Adaptation in the Yak: A Homeostatic Mechanism Mediated by Cell Adhesion Molecules.International journal of molecular sciences · 2026Article
- CircVPS13C Promotes Intramuscular Adipogenesis via MiR-5606-X-Biomolecules · 2026Article
- Integrated multiomics analysis reveals the molecular features and crucial regulators of hair follicles in yak (Bos grunniens).Communications biology · 2026Article
- Mechanisms and Applications of Gastrointestinal Microbiota-Metabolite Interactions in Ruminants: A Review.Microorganisms · 2025Review
- Exploring the genetic footprints of high altitude adapted humans and livestock.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- A Strategy for Single-Run Sequencing of the Water Buffalo Genome: (II) Fast One-Step Assembly of Highly Continuous Chromosome Sequences.Animals : an open access journal from MDPI · 2025Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wild yak (Bos mutus) and domestic yak (Bos grunniens) are adapted to high altitude environment and have ecological, economic, and cultural significances on the Qinghai-Tibetan Plateau (QTP). Currently, the genetic and cellular bases underlying adaptations of yak to extreme conditions remains elusive. In the present study, we assembled two chromosome-level genomes, one each for wild yak and domestic yak, and screened structural variants (SVs) through the long-read data of yak and taurine cattle. The results revealed that 6733 genes contained high-FST SVs. 127 genes carrying special type of SVs were differentially expressed in lungs of the taurine cattle and yak. We then constructed the first single-cell gene expression atlas of yak and taurine cattle lung tissues and identified a yak-specific endothelial cell subtype. By integrating SVs and single-cell transcriptome data, we revealed that the endothelial cells expressed the highest proportion of marker genes carrying high-FST SVs in taurine cattle lungs. Furthermore, we identified pathways which were related to the medial thickness and formation of elastic fibers in yak lungs. These findings provide new insights into the high-altitude adaptation of yak and have important implications for understanding the physiological and pathological responses of large mammals and humans to hypoxia.
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