ArticleJournal of agricultural and food chemistry2022
Investigations on the Transfer of Quinolizidine Alkaloids from
Article in Journal of agricultural and food chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Classification ofFrontiers in artificial intelligence · 2026Article
- A validated LC-MS/MS multi-method for the determination of 110 mycotoxins and plant toxins in cow milk and application to samples from Germany.Analytical and bioanalytical chemistry · 2025Article
- Alkaloid profile of Italian alpine milk.Journal of food science · 2025Article
- Review
- Article
- New Analytical Approach to Quinolizidine Alkaloids and Their Assumed Biosynthesis Pathways in Lupin Seeds.Toxins · 2024Review
- Development of an HPLC-MS/MS Method for the Determination of Alkaloids in Lupins.Molecules (Basel, Switzerland) · 2023Article
- Review
- Upcycling post-harvest biomass residues from native EuropeanFrontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lupin varieties with a low content of quinolizidine alkaloids (QAs) like blue sweet lupin (BSL) have long been used as a protein source for dairy cows. A health concern for humans may arise from the transfer of acute toxic QAs from feed into cow's milk. This study is the first to quantify the transfer of QAs from BSL into cow's milk with experimental and modeling methods. Four lactating dairy cows were subjected to two 7 day feeding periods with 1 and 2 kg/d BSL, respectively, each followed by a depuration period. BSL contained 1774 mg/kg dry matter total QAs. Individual milk samples were taken twice daily and QA contents in feed and milk determined with liquid chromatography-tandem mass spectrometry. Transfer of QAs into the milk was already seen with the administration of 1 kg/d BSL, with differences in transfer rates (TRs) between individual QAs. A toxicokinetic model was derived to quantify and predict QA feed-to-food transfer. For the four most prominent QAs, our model shows an α-half-life of around 0.27 d. TRs were obtained for six QAs and were between 0.13 (sparteine) and 3.74% (multiflorine). A toxicological assessment of milk containing QAs as measured in this study indicated a potential health concern.
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