ArticleClinical nutrition (Edinburgh, Scotland)2022
Coffee consumption and cancer risk: a Mendelian randomisation study.
Article in Clinical nutrition (Edinburgh, Scotland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Coffee and the Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies.Gut and liver · 2026Pooled it
- Assessing the genetic estimates of the association between plasma caffeine and cancer risk through Mendelian randomization.European journal of nutrition · 2025Pooled it
- A systematic review and dose-response meta-analysis of prospective cohort studies on coffee consumption and risk of lung cancer.Scientific reports · 2024Pooled it
- Application of Mendelian randomized research method in oncology research: bibliometric analysis.Frontiers in oncology · 2024Pooled it
- Coffee Consumption and Its Potential Implications for Digestive Tract Carcinogenesis.Current nutrition reports · 2026Review
- Unraveling the complexities of caffeine: metabolism, genetics, evolution, and health.Hereditas · 2026Review
- Genetic Evidence for Immune Cell-Lipid Mediation Pathways Linked to Esophageal Cancer and Associated Throat/Chest Pain Phenotypes.Journal of pain research · 2026Article
- Regulatory Effects of Coffee/Chlorogenic Acid and Tea/Epigallocatechin-3-Current issues in molecular biology · 2025Review
- Mendelian Randomization and Machine Learning Reveal Immune Cell and Gene Drivers in Systemic Lupus Erythematosus.Brain and behavior · 2025Article
- Association between coffee consumption and life expectancy: a prospective cohort study from NHANES 2001-2018.Public health nutrition · 2025Article
- Habitual sweet and bitter beverage consumption in relation to the risk of frailty and sarcopenia-related traits: a Mendelian randomization study.BMC geriatrics · 2025Article
- Genetically proxied risk and protective factors for pancreatic cancer: a systematic review and meta-analysis of Mendelian randomization studies.Journal of gastrointestinal oncology · 2025Article
- The associations between circulating amino acids and arterial aneurysms and dissection: A bidirectional Mendelian randomization study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Risk factors for multiple myeloma and its precursor diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Causal Assessment of Phenotypic Risk Factors with Keratinocyte Carcinoma.Phenomics (Cham, Switzerland) · 2025Article
- Coffee consumption, cancer, and healthy aging: epidemiological evidence and underlying mechanisms.GeroScience · 2025Review
- Article
- Behavioral risk factors in oncology patients: A matched case control study from Yemen.PloS one · 2025Article
- Comparison of caffeine consumption behavior with plasma caffeine levels as exposure measures in drug-target mendelian randomization.American journal of epidemiology · 2024Article
- Turkish coffee has an antitumor effect on breast cancer cells in vitro and in vivo.Nutrition & metabolism · 2024Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundCoffee contains many bioactive chemicals and associations with cancer have been reported in observational studies. In this Mendelian randomisation (MR) study we investigated the causal associations of coffee consumption with a broad range of cancers. MATERIALS AND
methodsTwelve independent genetic variants proxied coffee consumption. Genetically-predicted risk of any cancer (59,647 cases) and 22 site-specific cancers was estimated in European-descent individuals in UK Biobank. Univariable and multivariable MR analyses were conducted.
resultsGenetically-predicted coffee consumption was not associated with risk of any cancer in the main analysis (OR 1.05, 95% CI 0.98-1.14, p = 0.183) but was associated with an increased risk of digestive system cancer (OR 1.28, 95% CI 1.09-1.51, p = 0.003), driven by a strong association with oesophageal cancer (OR 2.79, 95% CI 1.73-4.50, p = 2.5×10
conclusionsThis MR study provides strong support for a causal association of coffee consumption with oesophageal cancer, but not for the majority of cancer types, and the underlying mechanisms require investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.