Evidence map›Paper›PMID 36067368›Full record

ArticleThe Journal of urology2023

Phenotyping of Urinary Urgency Patients Without Urgency Incontinence, and Their Comparison to Urgency Incontinence Patients: Findings From the LURN Study.

H Henry Lai, Jonathan B Wiseman, Margaret E Helmuth, Abigail R Smith, Cindy L Amundsen, Anne P Cameron, Alexander P Glaser, Whitney K Hendrickson, Ziya Kirkali, Kimberly Kenton

Open access · greenAbstract read
In one paragraph

Article in The Journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

H Henry LaiDivision of Urologic Surgery, Departments of Surgery and Anesthesiology, Washington University School of Medicine, St. Louis, Missouri.
Jonathan B WisemanArbor Research Collaborative for Health, Ann Arbor, Michigan.
Margaret E HelmuthArbor Research Collaborative for Health, Ann Arbor, Michigan.
Abigail R SmithArbor Research Collaborative for Health, Ann Arbor, Michigan.
Cindy L AmundsenDepartment of Obstetrics and Gynecology, Division of Urogynecology, Duke University, Durham, North Carolina.
Anne P CameronDepartment of Urology, University of Michigan, Ann Arbor, Michigan.
Alexander P GlaserNorthShore University HealthSystem, Evanston, Illinois.
Whitney K HendricksonDepartment of Obstetrics and Gynecology, Division of Urogynecology, Duke University, Durham, North Carolina.
Ziya KirkaliNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Kimberly KentonDepartment of Obstetrics & Gynecology, Division of Female Pelvic Medicine & Reconstructive Surgery, Northwestern University, Chicago, Illinois.
Arbor Research Collaborative for Health · USDuke University · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNorthShore University HealthSystem · USNorthwestern University · USUniversity of Michigan–Ann Arbor · USWashington University in St. Louis · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating CenterU24DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI GRAFF, JOHN JOSEPH · 2019 to 2025
$6.9M
Phenotype of urinary symptoms and relationships with genotype, sleep and obesityU01DK097779 · NIDDK · UNIVERSITY OF CHICAGO · PI GRIFFITH, JAMES WILLIAM, KENTON, KIMBERLY SUE · 2012 to 2025
$5.7M
Advancing the Measurement and Classification of Lower Urinary Tract DysfunctionU01DK097780 · NIDDK · DUKE UNIVERSITY · PI AMUNDSEN, CINDY, JELOVSEK, JOHN ERIC · 2012 to 2025
$5.3M
University of Iowa LURN Research SiteU01DK097772 · NIDDK · UNIVERSITY OF IOWA · PI BRADLEY, CATHERINE S, KREDER, KARL J · 2012 to 2025
$5.0M
Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)U01DK099879 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI MERION, ROBERT M · 2013 to 2018
$4.6M
University of Washington LURN Research SiteU01DK100011 · NIDDK · UNIVERSITY OF WASHINGTON · PI YANG, CLAIRE C · 2013 to 2025
$4.5M
University of Michigan LURN Research SiteU01DK099932 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLEMENS, J. QUENTIN · 2013 to 2023
$4.4M
Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Second Phase StudyU01DK100017 · NIDDK · WASHINGTON UNIVERSITY · PI LAI, HING HUNG HENRY · 2013 to 2025
$3.9M
NCATS NIH HHS UL1 TR001422NIDDK NIH HHS U01 DK097772NIDDK NIH HHS U01 DK097779NIDDK NIH HHS U01 DK097780NIDDK NIH HHS U01 DK099879NIDDK NIH HHS U01 DK099932NIDDK NIH HHS U01 DK100011NIDDK NIH HHS U01 DK100017NIDDK NIH HHS U24 DK099879
6 · The paper itself

Abstract

purposeWe characterize patients with urinary urgency with vs without urgency urinary incontinence who presented to clinics actively seeking treatment for their symptoms. MATERIALS AND

methodsParticipants who enrolled in the Symptoms of Lower Urinary Tract Dysfunction Research Network were categorized into urinary urgency with vs without urgency urinary incontinence. Participants were followed for 1 year; their urinary symptoms, urological pain, psychosocial factors, bowel function, sleep disturbance, physical activity levels, physical function, and quality of life were compared. Mixed effects linear regression models were used to examine the relationships between urgency urinary incontinence and these factors.

resultsAmong 683 participants with urinary urgency at baseline, two-thirds (n=453) also had urgency urinary incontinence; one-third (n=230) had urinary urgency-only without urgency urinary incontinence. No differences were detected in urological pain between urinary urgency-only and urgency urinary incontinence. Those with urgency urinary incontinence had more severe urgency and frequency symptoms, higher depression, anxiety, perceived stress scores, more severe bowel dysfunction and sleep disturbance, lower physical activity levels, lower physical function, and worse quality of life than those with urinary urgency-only. Among those with urinary urgency-only at baseline, 40% continued to have urinary urgency-only, 15% progressed to urgency urinary incontinence, and 45% had no urgency at 12 months. Fifty-eight percent with urgency urinary incontinence at baseline continued to report urgency urinary incontinence at 12 months, while 15% improved to urinary urgency-only, and 27% had no urgency.

conclusionsPatients with urgency urinary incontinence have severe storage symptoms, more psychosocial symptoms, poorer physical functioning, and worse quality of life. Our data suggested urgency urinary incontinence may be a more severe manifestation of urinary urgency, rather than urinary urgency and urgency urinary incontinence being distinct entities.

Indexed as

Sleep Wake DisordersUrinary IncontinenceUrination DisordersHumansPainQuality of LifeSurveys and QuestionnairesUrinary Incontinence, Urgelower urinary tract symptomsoveractiveurgencyurgency urinary incontinenceurinary bladder

Identifiers

PMID36067368
PMCPMC9742334
OpenAlexW4294817452

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.