Evidence map›Paper›PMID 36067333›Full record

ArticleScience signaling2022

c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by

Marine Oberkampf, Audrey Hamiot, Pamela Altamirano-Silva, Paula Bellés-Sancho, Yannick D N Tremblay, Nicholas DiBenedetto, Roland Seifert, Olga Soutourina, Lynn Bry, Bruno Dupuy and 1 more

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Cytoplasmic membrane vesicles fromFrontiers in microbiology · 2026
    Article
  2. Analysis of essential genes inJournal of bacteriology · 2025
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  3. Article
  4. Analysis of Essential Genes inbioRxiv : the preprint server for biology · 2025
    Article
  5. Germination and Outgrowth ofMicroorganisms · 2025
    Article
  6. Safety evaluation ofFrontiers in microbiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. The state of play of rodent models for the study ofJournal of medical microbiology · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Potent Bile Acid Microbial Metabolites ModulatePathogens (Basel, Switzerland) · 2023
    Article
  17. Article
  18. Systematic Design of Adenosine Analogs as Inhibitors of aJournal of medicinal chemistry · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Marine OberkampfInstitut Pasteur, Université Paris Cité, UMR-CNRS 6047, Laboratoire Pathogenèse des Bactéries Anaérobies, F-75015 Paris, France.ORCID 0000-0002-2991-6288
Audrey HamiotInstitut Pasteur, Université Paris Cité, UMR-CNRS 6047, Laboratoire Pathogenèse des Bactéries Anaérobies, F-75015 Paris, France.ORCID 0000-0002-1561-1854
Pamela Altamirano-SilvaCentro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.
Paula Bellés-SanchoInstitut Pasteur, Université Paris Cité, UMR-CNRS 6047, Laboratoire Pathogenèse des Bactéries Anaérobies, F-75015 Paris, France.ORCID 0000-0003-4547-0332
Yannick D N TremblayInstitut Pasteur, Université Paris Cité, UMR-CNRS 6047, Laboratoire Pathogenèse des Bactéries Anaérobies, F-75015 Paris, France.ORCID 0000-0001-8715-5571
Nicholas DiBenedettoMassachusetts Host-Microbiome Center, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4043-9881
Roland SeifertInstitute of Pharmacology and Research Core Unit Metabolomics, Hannover Medical School, Hannover, Germany.
Olga SoutourinaUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.ORCID 0000-0001-6439-7228
Lynn BryMassachusetts Host-Microbiome Center, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8792-8527
Bruno DupuyInstitut Pasteur, Université Paris Cité, UMR-CNRS 6047, Laboratoire Pathogenèse des Bactéries Anaérobies, F-75015 Paris, France.ORCID 0000-0001-7176-8453
Johann PeltierInstitut Pasteur, Université Paris Cité, UMR-CNRS 6047, Laboratoire Pathogenèse des Bactéries Anaérobies, F-75015 Paris, France.ORCID 0000-0003-3207-9465
Centre National de la Recherche Scientifique · FRBrigham and Women's Hospital · USMedizinische Hochschule Hannover · DEUniversidad de Costa Rica · CR

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Commensal control of C. difficile virulenceR01AI153605 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI BRY, LYNN · 2021 to 2025
$3.4M
NIAID NIH HHS R01 AI153605NIDDK NIH HHS P30 DK034854
6 · The paper itself

Abstract

To colonize the host and cause disease, the human enteropathogen

Indexed as

Clostridioides difficileAnimalsBacterial ProteinsBile Acids and SaltsClostridioidesDinucleoside PhosphatesHumansMiceBacterial ProteinsBile Acids and Saltscyclic diadenosine phosphateDinucleoside Phosphates

Identifiers

PMID36067333
PMCPMC9831359
OpenAlexW4294844728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.