Evidence map›Paper›PMID 36067314›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Mechanism by which T7 bacteriophage protein Gp1.2 inhibits

Bradley P Klemm, Deepa Singh, Cassandra E Smith, Allen L Hsu, Lucas B Dillard, Juno M Krahn, Robert E London, Geoffrey A Mueller, Mario J Borgnia, Roel M Schaaper

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

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  7. Biological Characterization and Genomic Analysis of Three NovelInternational journal of molecular sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Bradley P KlemmGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.ORCID 0000-0003-3484-3711
Deepa SinghGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.
Cassandra E SmithGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.
Allen L HsuGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.ORCID 0000-0003-2065-3802
Lucas B DillardGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.
Juno M KrahnGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.ORCID 0000-0002-4640-0267
Robert E LondonGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.
Geoffrey A MuellerGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.ORCID 0000-0001-8361-5323
Mario J BorgniaGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.ORCID 0000-0001-9159-1413
Roel M SchaaperGenome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709.ORCID 0000-0003-1344-3196
National Institutes of Health · US

Funding

NIEHS Cryo-EM Core FacilityZICES103326 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BORGNIA, MARIO · 2017 to 2025
$17.0M
Structure-function studies on Dgt triphosphohydrolaseZIAES101905 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SCHAAPER, ROELAND · 2009 to 2025
$14.6M
Structural and Functional Characterization of AllergensZIAES102906 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MUELLER, GEOFFREY · 2010 to 2025
$10.0M
Intramural NIH HHS ZIA ES101905Intramural NIH HHS ZIA ES102906Intramural NIH HHS ZIC ES103326
6 · The paper itself

Abstract

Levels of the cellular dNTPs, the direct precursors for DNA synthesis, are important for DNA replication fidelity, cell cycle control, and resistance against viruses.

Indexed as

Bacteriophage T7Escherichia coliEscherichia coli ProteinsGTP PhosphohydrolasesGuanosine TriphosphateViral ProteinsCryoelectron MicroscopyDNA ReplicationDNA, ViralProtein ConformationVirus ReplicationDNA, ViralEscherichia coli ProteinsGTP PhosphohydrolasesGuanosine TriphosphateViral Proteinsallosteric regulationcryo-EMdGTP triphosphohydrolaseenzyme inhibitionNMR

Identifiers

PMID36067314
PMCPMC9478638
OpenAlexW4294818102

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.