Evidence map›Paper›PMID 36067295›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Endocannabinoid-dependent formation of columnar axonal projection in the mouse cerebral cortex.

Chiaki Itami, Naofumi Uesaka, Jui-Yen Huang, Hui-Chen Lu, Kenji Sakimura, Masanobu Kano, Fumitaka Kimura

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Chiaki ItamiDepartment of Physiology, Faculty of Medicine, Saitama Medical University, Moroyama, Saitama 350-0495, Japan.
Naofumi UesakaDepartment of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.ORCID 0000-0002-9744-944X
Jui-Yen HuangThe Linda and Jack Gill Center for Biomolecular Sciences, Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.
Hui-Chen LuThe Linda and Jack Gill Center for Biomolecular Sciences, Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.ORCID 0000-0002-6628-7177
Kenji SakimuraDepartment of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan.
Masanobu KanoDepartment of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.ORCID 0000-0002-0725-3292
Fumitaka KimuraDepartment of Molecular Neuroscience, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.ORCID 0000-0002-7420-428X
Indiana University Bloomington · USGraduate School of Health Care Sciences, Jikei Institute · JPNiigata University · JPThe University of Tokyo · JPTokyo Medical and Dental University · JP

Funding

Mechanisms and treatment of adolescent phytocannabinoid impairment of prefrontal cortex functionR01DA053746 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HUI-CHEN LU, Kenneth Mackie · 2022 to 2026
$2.2M
NIDA NIH HHS R01 DA053746
6 · The paper itself

Abstract

Columnar structure is one of the most fundamental morphological features of the cerebral cortex and is thought to be the basis of information processing in higher animals. Yet, how such a topographically precise structure is formed is largely unknown. Formation of columnar projection of layer 4 (L4) axons is preceded by thalamocortical formation, in which type 1 cannabinoid receptors (CB1R) play an important role in shaping barrel-specific targeted projection by operating spike timing-dependent plasticity during development (Itami

Indexed as

AxonsCerebral CortexEndocannabinoidsAnimalsLipoprotein LipaseMiceMice, Mutant StrainsNeuronsReceptor, Cannabinoid, CB1Somatosensory CortexCNR1 protein, mouseEndocannabinoidsLipoprotein LipaseReceptor, Cannabinoid, CB1barrel cortexCB1Rcortical columnspike timing-dependent plasticity (STDP)

Identifiers

PMID36067295
PMCPMC9477236
OpenAlexW4294844616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.