Evidence map›Paper›PMID 36067293›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Combinatorial clustering of distinct DNA motifs directs synergistic binding of

Nicholas J Fuda, Katjuša Brejc, William S Kruesi, Edward J Ralston, Rachel Bigley, Aram Shin, Miki Okada, Barbara J Meyer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  5. Combinatorial clustering of distinct DNA motifs directs synergistic binding ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nicholas J FudaHHMI, University of California, Berkeley, CA 94720.ORCID 0000-0003-0886-2329
Katjuša BrejcHHMI, University of California, Berkeley, CA 94720.ORCID 0000-0002-4562-6109
William S KruesiHHMI, University of California, Berkeley, CA 94720.
Edward J RalstonHHMI, University of California, Berkeley, CA 94720.
Rachel BigleyHHMI, University of California, Berkeley, CA 94720.
Aram ShinHHMI, University of California, Berkeley, CA 94720.
Miki OkadaHHMI, University of California, Berkeley, CA 94720.ORCID 0000-0003-3482-8554
Barbara J MeyerHHMI, University of California, Berkeley, CA 94720.ORCID 0000-0002-6530-4588
University of California, Berkeley · US

Funding

Analysis of Nematode Sex Determination and Dosage CompensationR35GM131845 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MEYER, BARBARA J · 2019 to 2023
$2.3M
NIGMS NIH HHS R35 GM131845
6 · The paper itself

Abstract

Organisms that count X-chromosome number to determine sex utilize dosage compensation mechanisms to balance X-gene expression between sexes. Typically, a regulatory complex is recruited to X chromosomes of one sex to modulate gene expression. A major challenge is to determine the mechanisms that target regulatory complexes specifically to X. Here, we identify critical X-sequence motifs in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsDosage Compensation, GeneticAnimalsCluster AnalysisNucleotide MotifsX ChromosomeCaenorhabditis elegans ProteinsC. eleganscondensinDNA binding motifsgenome editingX-chromosome dosage compensation

Identifiers

PMID36067293
PMCPMC9477397
OpenAlexW4294795372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.