Evidence map›Paper›PMID 36067288›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Miat and interacting protein Metadherin maintain a stem-like niche to promote medulloblastoma tumorigenesis and treatment resistance.

Kai-Lin Peng, Harish N Vasudevan, Dennis T Lockney, Rachel Baum, Ronald C Hendrickson, David R Raleigh, Adam M Schmitt

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  8. Article
  9. Targeting epigenetic regulators to overcome drug resistance in cancers.Signal transduction and targeted therapy · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kai-Lin PengDivision of Translational Oncology, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
Harish N VasudevanDivision of Translational Oncology, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
Dennis T LockneyDivision of Translational Oncology, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
Rachel BaumDivision of Translational Oncology, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
Ronald C HendricksonMicrochemistry and Proteomics, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
David R RaleighDepartment of Radiation Oncology, University of California San Francisco, CA, 94143.
Adam M SchmittDivision of Translational Oncology, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
Memorial Sloan Kettering Cancer Center · USNeurological Surgery · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Investigating long noncoding RNAs as regulators of the p53 pathway functions.R35GM124909 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI SCHMITT, ADAM · 2017 to 2021
$2.2M
LTQ-ORBITRAP VELOS Tandem Mass SpectrometerS10OD010598 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI HENDRICKSON, RONALD CHARLES · 2012 to 2012
$460k
NCI NIH HHS P30 CA008748NIGMS NIH HHS R35 GM124909NIH HHS S10 OD010598
6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) play essential roles in the development and progression of many cancers. However, the contributions of lncRNAs to medulloblastoma (MB) remain poorly understood. Here, we identify

Indexed as

CarcinogenesisCerebellar NeoplasmsMedulloblastomaMembrane ProteinsMicroRNAsRNA-Binding ProteinsRNA, Long NoncodingHumansMembrane ProteinsMiat long non-coding RNAMicroRNAsMTDH protein, humanRNA-Binding ProteinsRNA, Long Noncodinglong noncoding RNAmedulloblastomaMetadherinMiat

Identifiers

PMID36067288
PMCPMC9478675
OpenAlexW4294795518

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.