ArticlePLoS computational biology2022
What lies underneath: Precise classification of brain states using time-dependent topological structure of dynamics.
Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Disrupted hierarchical organization in disorders of consciousness revealed by fluctuation-dissipation deviations.bioRxiv : the preprint server for biology · 2025Article
- Re-awakening the brain: Forcing transitions in disorders of consciousness by external in silico perturbation.PLoS computational biology · 2024Article
- Consciousness, 4E cognition and Aristotle: a few conceptual and historical aspects.Frontiers in computational neuroscience · 2023Review
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Authors and funding
15 authors.
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Abstract
The self-organising global dynamics underlying brain states emerge from complex recursive nonlinear interactions between interconnected brain regions. Until now, most efforts of capturing the causal mechanistic generating principles have supposed underlying stationarity, being unable to describe the non-stationarity of brain dynamics, i.e. time-dependent changes. Here, we present a novel framework able to characterise brain states with high specificity, precisely by modelling the time-dependent dynamics. Through describing a topological structure associated to the brain state at each moment in time (its attractor or 'information structure'), we are able to classify different brain states by using the statistics across time of these structures hitherto hidden in the neuroimaging dynamics. Proving the strong potential of this framework, we were able to classify resting-state BOLD fMRI signals from two classes of post-comatose patients (minimally conscious state and unresponsive wakefulness syndrome) compared with healthy controls with very high precision.
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