Evidence map›Paper›PMID 36067224›Full record

ArticlePLoS computational biology2022

EpiBeds: Data informed modelling of the COVID-19 hospital burden in England.

Christopher E Overton, Lorenzo Pellis, Helena B Stage, Francesca Scarabel, Joshua Burton, Christophe Fraser, Ian Hall, Thomas A House, Chris Jewell, Anel Nurtay and 2 more

Abstract read
In one paragraph

Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Estimation of reproduction numbers in real time: Conceptual and statistical challenges.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christopher E OvertonDepartment of Mathematics, University of Manchester, Manchester United Kingdom.ORCID 0000-0002-8433-4010
Lorenzo PellisDepartment of Mathematics, University of Manchester, Manchester United Kingdom.
Helena B StageDepartment of Mathematics, University of Manchester, Manchester United Kingdom.ORCID 0000-0001-9938-8452
Francesca ScarabelDepartment of Mathematics, University of Manchester, Manchester United Kingdom.ORCID 0000-0003-0250-4555
Joshua BurtonFaculty of Biology Medicine and Health, Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, United Kingdom.ORCID 0000-0001-8530-0464
Christophe FraserBig Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Ian HallDepartment of Mathematics, University of Manchester, Manchester United Kingdom.
Thomas A HouseDepartment of Mathematics, University of Manchester, Manchester United Kingdom.
Chris JewellCHICAS, Lancaster Medical School, Lancaster University, Lancaster, United Kingdom.
Anel NurtayBig Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-7107-1656
Filippo PaganiDepartment of Mathematics, University of Manchester, Manchester United Kingdom.
Katrina A LythgoeBig Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

Funding

Analysis of RhoGTPase function in neural crest EMT in vivoR21NS073114 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI HALLORAN, MARY C · 2011 to 2012
$401k
Department of HealthMedical Research Council MR/V038613/1NINDS NIH HHS R21 NS073114Wellcome TrustWellcome Trust 107652/Z/15/ZWellcome Trust 202562/Z/16/ZWellcome Trust 219992/Z/19/ZWellcome Trust UNS73114
6 · The paper itself

Abstract

The first year of the COVID-19 pandemic put considerable strain on healthcare systems worldwide. In order to predict the effect of the local epidemic on hospital capacity in England, we used a variety of data streams to inform the construction and parameterisation of a hospital progression model, EpiBeds, which was coupled to a model of the generalised epidemic. In this model, individuals progress through different pathways (e.g. may recover, die, or progress to intensive care and recover or die) and data from a partially complete patient-pathway line-list was used to provide initial estimates of the mean duration that individuals spend in the different hospital compartments. We then fitted EpiBeds using complete data on hospital occupancy and hospital deaths, enabling estimation of the proportion of individuals that follow the different clinical pathways, the reproduction number of the generalised epidemic, and to make short-term predictions of hospital bed demand. The construction of EpiBeds makes it straightforward to adapt to different patient pathways and settings beyond England. As part of the UK response to the pandemic, EpiBeds provided weekly forecasts to the NHS for hospital bed occupancy and admissions in England, Wales, Scotland, and Northern Ireland at national and regional scales.

Indexed as

COVID-19EnglandHospitalizationHospitalsHumansPandemics

Identifiers

PMID36067224
PMCPMC9481171

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.