ArticleAngewandte Chemie (International ed. in English)2022
Phase Transitions in Chemically Fueled, Multiphase Complex Coacervate Droplets.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Design of Fuel-Dependent, Complex-Coacervate-Based Synthetic Cells.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Dynamic and Catalytic Multiphase Coacervates.Biomacromolecules · 2026Article
- Adaptive Coacervate Microreactors with Broad pH/Thermal Tolerance for Reaction Acceleration.JACS Au · 2026Article
- Numerical Modeling of a Reactive Liquid-Solid Phase Transformation in Molten Steel.Materials (Basel, Switzerland) · 2026Article
- Preservation of Complex Multiphase Architectures in Polymer-Based Artificial Cells by Photo-Crosslinking.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Curcumin coacervates for supramolecular-interaction-responsive cytosolic siRNA delivery to enhance pyroptosis.Theranostics · 2026Article
- Enzymatically reconfigurable liquid crystalline coacervate microdroplets as protocell models.Nature communications · 2025Article
- Chemically Fueled, Active Droplets Prevent the Aging of Peptides into Amyloid-Like Fibers.Journal of the American Chemical Society · 2025Article
- Non-equilibrium demixing and dissolution of chiral coacervates via intrinsic catalysis.Nature communications · 2025Article
- Dual-Stimulus Programmed Multiphase Separation and Organization in Coacervate Droplets.Angewandte Chemie (International ed. in English) · 2025Article
- Interfacial effects determine nonequilibrium phase behaviors in chemically driven fluids.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Size control and oscillations of active droplets in synthetic cells.Nature communications · 2025Article
- Organelle-like structural evolution of coacervate droplets induced by photopolymerization.Nature communications · 2025Article
- Coacervate Droplets as Biomimetic Models for Designing Cell-Like Microreactors.Macromolecular rapid communications · 2024Review
- Did the exposure of coacervate droplets to rain make them the first stable protocells?Science advances · 2024Article
- Multicompartmental coacervate-based protocell by spontaneous droplet evaporation.Nature communications · 2024Article
- Forging out-of-equilibrium supramolecular gels.Nature synthesis · 2024Article
- Suppressing catalyst poisoning in the carbodiimide-fueled reaction cycle.Chemical science · 2023Article
- Liquid spherical shells are a non-equilibrium steady state of active droplets.Nature communications · 2023Article
- Chemically Fueled Supramolecular Materials.Accounts of materials research · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membraneless organelles are droplets in the cytosol that are regulated by chemical reactions. Increasing studies suggest that they are internally organized. However, how these subcompartments are regulated remains elusive. Herein, we describe a complex coacervate-based model composed of two polyanions and a short peptide. With a chemical reaction cycle, we control the affinity of the peptide for the polyelectrolytes leading to distinct regimes inside the phase diagram. We study the transitions from one regime to another and identify new transitions that can only occur under kinetic control. Finally, we show that the chemical reaction cycle controls the liquidity of the droplets offering insights into how active processes inside cells play an important role in tuning the liquid state of membraneless organelles. Our work demonstrates that not only thermodynamic properties but also kinetics should be considered in the organization of multiple phases in droplets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.