Evidence map›Paper›PMID 36066918›Full record

ArticleJournal of cancer biology2021

Chromatin dynamics: Nucleosome occupancy and sensitivity as determinants of gene expression and cell fate.

Jane Benoit, Mahdi Khadem Sheikhbahaei, Jonathan Dennis

Open access · greenAbstract read
In one paragraph

Article in Journal of cancer biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jane BenoitDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Mahdi Khadem SheikhbahaeiDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Jonathan DennisDepartment of Biological Science, Florida State University, Tallahassee, FL 32306, USA.
Florida State University · US

Funding

Chromatin structural changes linking drugs of abuse with HIV reactivationR01DA033775 · NIDA · FLORIDA STATE UNIVERSITY · PI DENNIS, JONATHAN H · 2012 to 2016
$1.8M
NIDA NIH HHS R01 DA033775
6 · The paper itself

Abstract

The nucleosome, consisting of ~150bp of DNA wrapped around a core histone octamer, is a regulator of nuclear events that contributes to gene expression and cell fate. Nucleosome organization at promoters and their associated remodeling events are important regulators of access to the genome. Occupancy alone, however, is not the only nucleosomal characteristic that plays a role in genome regulation. Nucleosomes at the transcription start sites (TSSs) of genes show differential sensitivity to micrococcal nuclease (MNase) and this differential sensitivity is linked to transcription and regulatory factor binding events. Recently, lymphoblastoid cells treated with heat-killed

Indexed as

AdenocarcinomaChromatin remodelingEpigeneticsGene regulationNucleosome

Identifiers

PMID36066918
PMCPMC9435377
OpenAlexW4247459322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.