Evidence map›Paper›PMID 36066675›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Seizure treatment with olfactory training: a preliminary trial.

Yasin Yilmaz, Bengi Gul Turk, Merve Hazal Ser, Nursah Yeniay Sut, Suleyman Sahin, Edibe Pembegul Yildiz, Gonca Bektas, Serap Tiras Teber, Hakan Tekeli, Cigdem Ozkara

Registry-linked trialAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07116421 (Effect of 2-phenylethanol Odor Exposure on Ictal Apneic Episode Occurrence Rate in Patients With Epilepsy), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07116421 early_phase1recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of 2-phenylethanol Odor Exposure on Ictal Apneic Episode Occurrence Rate in Patients With Epilepsy

TypeinterventionalSponsorVanderbilt University Medical CenterRan2025 to 2027Enrolled40ConditionsEpilepsy, Sudden Unexpected Death in EpilepsyArms2-phenylethanol rose scent
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Yasin YilmazDepartment of Neuroscience, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Turkey. dryasinyilmaz@gmail.com.ORCID http://orcid.org/0000-0002-4811-5750
Bengi Gul TurkDepartment of Neurology, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Koca Mustafapasa Cd. No: 53, 34096, Fatih, Istanbul, Turkey.
Merve Hazal SerDepartment of Neurology, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Koca Mustafapasa Cd. No: 53, 34096, Fatih, Istanbul, Turkey.
Nursah Yeniay SutDepartment of Pediatric Neurology, Ankara University School of Medicine, Ankara, Turkey.
Suleyman SahinDepartment of Pediatric Neurology, Ankara University School of Medicine, Ankara, Turkey.
Edibe Pembegul YildizDepartment of Pediatric Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Gonca BektasDepartment of Pediatric Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Serap Tiras TeberDepartment of Pediatric Neurology, Ankara University School of Medicine, Ankara, Turkey.
Hakan TekeliDepartment of Neurology, Sultan Abdulhamid Han Research and Training Hospital, University of Health Science, Istanbul, Turkey.
Cigdem OzkaraDepartment of Neurology, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Koca Mustafapasa Cd. No: 53, 34096, Fatih, Istanbul, Turkey.
Ankara University · TRIstanbul University · TRIstanbul University-Cerrahpaşa · TRSağlık Bilimleri Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEpilepsy is a chronic condition characterized by recurrent seizures. Despite miscellaneous antiseizure medications, resistance to treatment is still approximately 30%. This resistance brings forward the multidisciplinary approach and complementary treatments. In this study, we aimed to investigate the effect of olfactory training on epileptic seizures with special aromas having antiseizure effects in patients diagnosed with drug-resistant epilepsy.

methodsA total of 24 patients (14 pediatric and 10 adults) with drug-resistant epilepsy were recruited for the study. Participants were asked to inhale the standardized bottle filled with lavender aroma (Lavandula Angustifolia) twice a day (morning and evening) for 30-45 s (2 cm in front of nose; 10-15 s to right and left nostril and 10-15 s to both nostrils) for 3 months. The type, frequency, duration of seizures, the quality of life (SF-36 and PedsQL 4.0), and olfactory functions (Sniffin' Sticks Test and Pediatric Smell Wheel) were re-assessed.

resultsStatistical analysis showed that olfactory training decreased the seizure frequency (p < 0.001) and the seizure duration (p = 0.02). A global 50% seizure reduction was seen among patients. Moreover, olfactory training increased the quality of life (p = 0.003) and improved the olfactory function in both the pediatric and adult groups (p = 0.017, p = 0.05, respectively). There was no adverse reaction and no increase in seizure frequency. SIGNIFICANCE: The observations of the present investigation suggest that olfactory training is a successful complementary therapy with no adverse reaction in patients with drug-resistant epilepsy. Large cohort studies and longer follow-up periods are needed for providing olfactory training as a therapy modality in patients with epilepsy.

Indexed as

Drug Resistant EpilepsyEpilepsyOlfaction DisordersAdultChildHumansQuality of LifeSeizuresSmellEpilepsyOlfactory dysfunctionOlfactory trainingSense of smell

Identifiers

PMID36066675
OpenAlexW4294723724

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.