Evidence map›Paper›PMID 36066629›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Distinct sleep disturbance and cognitive dysfunction profiles in oncology outpatients receiving chemotherapy.

Vivian Huang, Lynda Mackin, Kord M Kober, Steven M Paul, Bruce A Cooper, Yvette P Conley, Marilyn J Hammer, Jon D Levine, Christine Miaskowski

Abstract read
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Vivian HuangSchool of Nursing, University of California, 2 Koret Way - Box 0610, San Francisco, CA, 94143-0610, USA.
Lynda MackinSchool of Nursing, University of California, 2 Koret Way - Box 0610, San Francisco, CA, 94143-0610, USA.
Kord M KoberSchool of Nursing, University of California, 2 Koret Way - Box 0610, San Francisco, CA, 94143-0610, USA.
Steven M PaulSchool of Nursing, University of California, 2 Koret Way - Box 0610, San Francisco, CA, 94143-0610, USA.
Bruce A CooperSchool of Nursing, University of California, 2 Koret Way - Box 0610, San Francisco, CA, 94143-0610, USA.
Yvette P ConleySchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Marilyn J HammerDana Farber Cancer Institute, Boston, MA, USA.
Jon D LevineSchool of Medicine, University of California, San Francisco, CA, USA.
Christine MiaskowskiSchool of Nursing, University of California, 2 Koret Way - Box 0610, San Francisco, CA, 94143-0610, USA. chris.miaskowski@ucsf.edu.ORCID http://orcid.org/0000-0001-5170-2027
University of California, San Francisco · USDana-Farber Cancer Institute · USUniversity of Pittsburgh · US

Funding

Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
NCI NIH HHS CA134900
6 · The paper itself

Abstract

purposeSleep disturbance and cancer-related cognitive impairment (CRCI) are two of the most common symptoms reported by patients undergoing chemotherapy. Less is known about how these symptoms co-occur and their associated risk factors. Study purposes were to identify subgroups of patients with distinct sleep disturbance and CRCI profiles and evaluate for differences among the subgroups in demographic and clinical characteristics, symptom severity scores, and QOL outcomes.

methodsA total of 1,333 oncology outpatients receiving chemotherapy completed self-report questionnaires on sleep disturbance and cognitive dysfunction six times over two cycles of chemotherapy. Latent profile analysis was used to identify distinct sleep disturbance AND cognitive dysfunction profiles. Parametric and non-parametric tests were used to evaluate for differences among the classes.

resultsTwo distinct profiles were identified (i.e., Low = low levels of both sleep disturbance and cognitive dysfunction (53.5%); High = high levels of both sleep disturbance and cognitive dysfunction (45.5%)). Patients in the High class were younger, more likely to be female, had a lower functional status and a higher level of comorbidity. In addition, these patients had a higher symptom burden and a lower quality of life.

conclusionAlmost half of the patients undergoing chemotherapy experienced clinically meaningful levels of both symptoms. Of note, sleep disturbance is frequently overlooked by both clinicians and patients. Clinicians need to recommend cognitive rehabilitation and physical activity programs to decrease patients' symptom burden.

Indexed as

Cognitive DysfunctionNeoplasmsSleep Wake DisordersDepressionFatigueFemaleHumansMaleOutpatientsQuality of LifeSleepCancerChemotherapyCognitive impairmentDepressionFatigueInsomniaPainQuality of lifeSleep disturbance

Identifiers

PMID36066629
OpenAlexW4294771046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.