Evidence map›Paper›PMID 36066237›Full record

ArticleAntimicrobial agents and chemotherapy2022

Multidrug-Resistant Gram-Negative Bacteria in Burn Patients.

Laura Ruegsegger, Jamie Xiao, Arash Naziripour, Trey Kanumuambidi, Dylan Brown, Felicia Williams, Steven H Marshall, Susan D Rudin, Kelly Yen, Tingyu Chu and 6 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Epidemiology and timing of infectious complications from battlefield-related burn injuries.Burns : journal of the International Society for Burn Injuries · 2024
    Article
  9. Article
  10. Multidrug-Resistant Organisms: The Silent Plight of Burn Patients.Journal of burn care & research : official publication of the American Burn Association · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Panomics to decode virulence and fitness in Gram-negative bacteria.Frontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Laura RuegseggerDivision of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.
Jamie XiaoDivision of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.
Arash NaziripourDivision of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.
Trey KanumuambidiDivision of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.
Dylan BrownDivision of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.
Felicia WilliamsDepartment of Surgery, University of North Carolina, Chapel Hill, North Carolina, USA.
Steven H MarshallLouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Susan D RudinLouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Kelly YenCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Tingyu ChuCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Liang ChenCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0001-5845-2235
Emanuele SozziDepartment of Environmental Science and Engineering, UNC Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Luther BarteltDivision of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.
Barry KreiswirthCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Robert A BonomoLouis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.ORCID 0000-0002-3299-894X
David van DuinDivision of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0003-4784-3227
University of North Carolina at Chapel Hill · USHackensack Meridian Health · USLouis Stokes Cleveland VA Medical Center · US

Funding

National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7M
The molecular basis of the epidemic blaKPC gene KlebsiellaR01AI090155 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KREISWIRTH, BARRY NEAL · 2011 to 2021
$7.2M
Bacterial Characteristics of Community-associated Carbapenem-Resistant EnterobacteriaceaeR01AI143910 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VAN DUIN, DAVID · 2019 to 2023
$1.9M
BLRD VA I01 BX001974NIAID NIH HHS R01 AI090155NIAID NIH HHS R01 AI143910NIH HHS P40 OD010995
6 · The paper itself

Abstract

Patients with burn injuries are at high risk for infectious complications, and infections are the most common cause of death after the first 72 h of hospitalization. Hospital-acquired infections caused by multidrug resistant (MDR) Gram-negative bacteria (GNB) in this population are concerning. Here, we evaluated carriage with MDR GNB in patients in a large tertiary-care burn intensive care unit. Twenty-nine patients in the burn unit were screened for intestinal carriage. Samples were cultured on selective media. Median time from admission to the burn unit to first sample collection was 9 days (IQR 5 - 17 days). In 21 (72%) patients, MDR GNB were recovered; the most common bacterial species isolated was Pseudomonas aeruginosa, which was found in 11/29 (38%) of patients. Two of these patients later developed bloodstream infections with P. aeruginosa. Transmission of KPC-31-producing ST22 Citrobacter freundii was detected. Samples from two patients grew genetically similar C. freundii isolates that were resistant to ceftazidime-avibactam. On analysis of whole-genome sequencing,

Indexed as

Gram-Negative BacteriaGram-Negative Bacterial InfectionsAnti-Bacterial AgentsAzabicyclo Compoundsbeta-LactamasesCeftazidimeDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsPseudomonas aeruginosaAnti-Bacterial AgentsAzabicyclo Compoundsbeta-LactamasesCeftazidimeburncarbapenemaseceftazidime-avibactamCitrobacterhospital infectionsplasmid-mediated resistancePseudomonas aeruginosa

Identifiers

PMID36066237
PMCPMC9487463
OpenAlexW4294755890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.