ArticlePhysiological reports2022
Pattern of gonadotropin secretion along the estrous cycle of C57BL/6 female mice.
Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin-releasing hormone neurons in female mice.Journal of neuroendocrinology · 2026Article
- Aging disrupts spatiotemporal coordination in the cycling murine ovary.Nature aging · 2026Article
- Profile of gonadotropin secretion in male and female rats determined in the tail-tip blood by ultrasensitive ELISA.Journal of neuroendocrinology · 2026Article
- Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin-releasing hormone neurons in female mice.bioRxiv : the preprint server for biology · 2026Article
- Vesicular GABA transport expression in kisspeptin cells may contribute to the preovulatory gonadotropin surge.Frontiers in endocrinology · 2026Article
- Mouse serum facilitates the expansion of the follicular cavity regardless of the estrous cycle phase.Journal of ovarian research · 2025Article
- Characterization and Regulation of the Neonatal Growth Hormone Surge.Endocrinology · 2024Article
- Collection and Analysis of Vaginal Smears to Assess Reproductive Stage in Mice.Current protocols · 2023Article
- Pattern of gonadotropin secretion along the estrous cycle of C57BL/6 female mice.Physiological reports · 2022Article
- Optogenetic stimulation of Kiss1Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pattern of gonadotropin secretion along the estrous cycle was elegantly described in rats. Less information exists about the pattern of gonadotropin secretion in gonad-intact mice, particularly regarding the follicle-stimulating hormone (FSH). Using serial blood collections from the tail-tip of gonad-intact C57BL/6 mice on the first day of cornification (transition from diestrus to estrus; hereafter called proestrus), we observed that the luteinizing hormone (LH) and FSH surge cannot be consistently detected since only one out of eight females (12%) showed increased LH levels. In contrast, a high percentage of mice (15 out of 21 animals; 71%) exhibited LH and FSH surges on the proestrus when a single serum sample was collected. Mice that exhibited LH and FSH surges on the proestrus showed c-Fos expression in gonadotropin-releasing hormone- (GnRH; 83.4% of co-localization) and kisspeptin-expressing neurons (42.3% of co-localization) of the anteroventral periventricular nucleus (AVPV). Noteworthy, mice perfused on proestrus, but that failed to exhibit LH surge, showed a smaller, but significant expression of c-Fos in GnRH (32.7%) and AVPV
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