Evidence map›Paper›PMID 36065853›Full record

ArticlePhysiological reports2022

Testing oxygenated microbubbles via intraperitoneal and intrathoracic routes on a large pig model of LPS-induced acute respiratory distress syndrome.

Riaz Ur Rehman Mohammed, Nathaniel T Zollinger, Andrea R McCain, Roser Romaguera-Matas, Seth P Harris, Keely L Buesing, Mark A Borden, Benjamin S Terry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Riaz Ur Rehman MohammedBiomedical Engineering Program, Department of Mechanical and Material Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.ORCID 0000-0002-3427-6895
Nathaniel T ZollingerBiomedical Engineering Program, Department of Mechanical and Material Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.ORCID 0000-0003-0044-064X
Andrea R McCainInstitutional Animal Care Program, Office of Research & Economic Development, University of Nebraska - Lincoln, Lincoln, Nebraska, USA.ORCID 0000-0002-8314-1866
Roser Romaguera-MatasInstitutional Animal Care Program, Office of Research & Economic Development, University of Nebraska - Lincoln, Lincoln, Nebraska, USA.
Seth P HarrisSchool of Veterinary Medicine and Biomedical Sciences, University of Nebraska - Lincoln Institute of Agriculture and Natural Resources, Lincoln, Nebraska, USA.
Keely L BuesingDepartment of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Mark A BordenBiomedical Engineering Program, University of Colorado, Boulder, Colorado, USA.
Benjamin S TerryBiomedical Engineering Program, Department of Mechanical and Material Engineering, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
University of Nebraska–Lincoln · USBrigham Young University · USUniversity of Colorado Boulder · USUniversity of Nebraska Medical Center · US

Funding

Peritoneal Oxygen Delivery For The Treatment Of Acute Respiratory Distress SyndromeR01HL151151 · NHLBI · UNIVERSITY OF COLORADO · PI BORDEN, MARK ANDREW, BUESING, KEELY · 2020 to 2023
$2.5M
NHLBI NIH HHS R01 HL151151
6 · The paper itself

Abstract

With a mortality rate of 46% before the onset of COVID-19, acute respiratory distress syndrome (ARDS) affected 200,000 people in the US, causing 75,000 deaths. Mortality rates in COVID-19 ARDS patients are currently at 39%. Extrapulmonary support for ARDS aims to supplement mechanical ventilation by providing life-sustaining oxygen to the patient. A new rapid-onset, human-sized pig ARDS model in a porcine intensive care unit (ICU) was developed. The pigs were nebulized intratracheally with a high dose (4 mg/kg) of the endotoxin lipopolysaccharide (LPS) over a 2 h duration to induce rapid-onset moderate-to-severe ARDS. They were then catheterized to monitor vitals and to evaluate the therapeutic effect of oxygenated microbubble (OMB) therapy delivered by intrathoracic (IT) or intraperitoneal (IP) administration. Post-LPS administration, the PaO

Indexed as

COVID-19Respiratory Distress SyndromeAnimalsHumansLipopolysaccharidesMicrobubblesRespiration, ArtificialSwineLipopolysaccharidesacute respiratory distress syndromeBerlin criteriaintraperitonealintrathoracicoxygenated microbubblesperipheral oxygenation

Identifiers

PMID36065853
PMCPMC9446406
OpenAlexW4294719221

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.