ArticleUnited European gastroenterology journal2022
Liver and spleen volumes are associated with prognosis of compensated and decompensated cirrhosis and parallel its natural history.
Article in United European gastroenterology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- MRI-Derived Evaluation of Liver Function and Its Extension to K-Edge Photon-Counting CT: Focus on Gadolinium-Based Functional Biliary Imaging.Diagnostics (Basel, Switzerland) · 2026Review
- Development of a clinical-CT-radiomics nomogram for predicting endoscopic red color sign in cirrhotic patients with esophageal varices.Abdominal radiology (New York) · 2026Article
- Risk factors for significant hepatic fibrosis in alcoholic liver disease and construction of a nomogram prediction model.BMC gastroenterology · 2026Article
- Radiological Approach to Splenomegaly: Etiologies, Pathophysiologies, and Diagnostic Strategies.Korean journal of radiology · 2026Review
- Hepatosplenic Volumes and Portal Pressure Gradient Identify One-year Further Decompensation Risk Post-transjugular Intrahepatic Portosystemic Shunt.Journal of clinical and translational hepatology · 2025Article
- [Non-invasive evaluation and prediction of portal hypertension: focusing on disease progression and outcome].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025Review
- U-Shaped Relationship Between CT-Measured Liver-To-Spleen Volume Ratio and Mortality in HBV-ACLF Patients.Journal of viral hepatitis · 2025Article
- Advances in Extracellular Matrix-Associated Diagnostics and Therapeutics.Journal of clinical medicine · 2025Review
- Predicting Chronic Liver Disease Severity by Liver and Splenic Extracellular Volume Fraction Derived from spectral-CT.Current medical imaging · 2025Article
- Artificial intelligence-based evaluation of prognosis in cirrhosis.Journal of translational medicine · 2024Review
- Computed Tomographic Findings of Liver Cirrhosis in Dogs: Comparison between Compensated and Decompensated Cirrhosis.Veterinary sciences · 2024Article
- CT-derived liver and spleen volume accurately diagnose clinically significant portal hypertension in patients with hepatocellular carcinoma.JHEP reports : innovation in hepatology · 2023Article
- Can we predict the future of patients with liver cirrhosis using volumetrics?United European gastroenterology journal · 2022Article
- Liver and spleen volumes are associated with prognosis of compensated and decompensated cirrhosis and parallel its natural history.United European gastroenterology journal · 2022Article
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Abstract
objectiveCirrhosis is characterized by the complex interplay among biological, histological and haemodynamic events. Liver and spleen remodelling occur throughout its natural history, but the prognostic role of these volumetric changes is unclear. We evaluated the relationship between volumetric changes assessed by multidetector computerised tomography (MDCT) and landmark features of cirrhosis.
methodsWe included consecutive cirrhotic patients who underwent liver transplantation (LT) or hepatocellular carcinoma (HCC) resection in whom dynamic MDCT was available. Different volumetric indices were calculated. Fibrosis was evaluated by the collagen proportional area and Laennec sub-stages. Correlation and logistic regression analysis were performed to explore associations of volumetric indexes and fibrosis with key prognostic features across the clinical stages of cirrhosis.
results185 patients were included (146 LT; 39 HCC); the predominant aetiology was viral hepatitis (51.35%); 65.9% had decompensated disease and 85.08% clinically significant portal hypertension (CSPH). The standardised liver volume and liver-spleen volume ratio negatively correlated with Model for End-stage Liver Disease (MELD), albumin and hepatic venous pressure gradient (HVPG) and were significantly lower in decompensated patients. The liver segmental volume ratio (segments I-III/segments IV-VIII) best captured the characteristic features of the compensated phase, showing a positive correlation with HVPG and a good discrimination between patients with and without CSPH and varices. Volumetric changes and fibrosis severity were independently associated with key prognostic events, with no association between these two parameters.
conclusionsLiver and spleen volumetric indices evolve differently along the natural history of cirrhosis and are associated with key prognostic factors in each phase, regardless of fibrosis severity and portal hypertension.
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