Evidence map›Paper›PMID 36065730›Full record

ArticleThe Journal of antimicrobial chemotherapy2022

Country data on AMR in Brazil in the context of community-acquired respiratory tract infections: links between antibiotic susceptibility, local and international antibiotic prescribing guidelines, access to medicine and clinical outcome.

Didem Torumkuney, Puja Nijhara, Cristiana Ossaille Beltrame, Elisama Queiroz Baisch, Ricardo Macarini Ferreira

Open access · hybridAbstract read
In one paragraph

Article in The Journal of antimicrobial chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Didem TorumkuneyGlaxoSmithKline, 980 Great West Road, Brentford, Middlesex TW8 9GS, UK.
Puja NijharaGlaxoSmithKline, 252, Dr Annie Besant Road, Worli 400030, Mumbai, India.
Cristiana Ossaille BeltrameGlaxoSmithKline, Estrada dos Bandeirantes, 8464, Jacarepaguá, 22783-110 Rio de Janeiro, Brazil.
Elisama Queiroz BaischGlaxoSmithKline, Estrada dos Bandeirantes, 8464, Jacarepaguá, 22783-110 Rio de Janeiro, Brazil.
Ricardo Macarini FerreiraGlaxoSmithKline, Estrada dos Bandeirantes, 8464, Jacarepaguá, 22783-110 Rio de Janeiro, Brazil.
GlaxoSmithKline (Brazil) · BRGlaxoSmithKline (India) · INGlaxoSmithKline (United Kingdom) · GB

Funding

GlaxoSmithKline
6 · The paper itself

Abstract

backgroundAntimicrobial resistance (AMR) is one of the biggest threats to global public health. Selection of resistant bacteria is driven by inappropriate use of antibiotics, amongst other factors. COVID-19 may have exacerbated AMR due to unnecessary antibiotic prescribing. Country-level knowledge is needed to understand options for action.

objectivesTo review the situation with respect to AMR in Brazil and initiatives addressing it. Identifying areas where more information is required will provide a call to action to minimize any further rises in AMR within Brazil and to improve patient outcomes.

methodsNational initiatives to address AMR, antibiotic use and prescribing in Brazil, and availability of susceptibility data, particularly for the key community-acquired respiratory tract infections (CA-RTI) pathogens Streptococcus pneumoniae and Haemophilus influenzae, were identified. National and international antibiotic prescribing guidelines for CA-RTIs (community-acquired pneumonia, acute otitis media and acute bacterial rhinosinusitis) commonly used locally were also reviewed, along with local antibiotic availability.

conclusionsIn Brazil there have been some initiatives addressing AMR such as the National Action Plan for AMR, established in 2018. Antibiotic consumption in Brazil is high but a ban on over-the-counter sales of antibiotics has led to a decrease in consumption. Local antibiotic susceptibility testing needs to be increased and the Survey of Antibiotic Resistance (SOAR) study in Brazil will provide useful data for pathogens causing CA-RTIs. A more standardized inclusive approach in developing local guidelines, using up-to-date surveillance data of isolates from community-acquired infections in Brazil, could make guideline use more locally relevant for clinicians. This would pave the way for a higher level of appropriate antibiotic prescribing and improved adherence. This would, in turn, potentially limit AMR development and improve clinical outcomes for patients.

Indexed as

Community-Acquired InfectionsCOVID-19PneumoniaRespiratory Tract InfectionsAcute DiseaseAnti-Bacterial AgentsBrazilHealth Services AccessibilityHumansAnti-Bacterial Agents

Identifiers

PMID36065730
PMCPMC9445857
OpenAlexW4294724537

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.