ArticleJournal of cachexia, sarcopenia and muscle2022
The effect of computed tomography parameters on sarcopenia and myosteatosis assessment: a scoping review.
Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Defining Reference Values for Skeletal Muscle Metrics on Abdominal CT Using Data From Healthy Young Adult Populations: A Systematic Review and Meta-Analysis.AJR. American journal of roentgenology · 2025Pooled it
- Prevalence and impact on the outcome of myosteatosis in patients with cirrhosis: a systematic review and meta-analysis.Hepatology international · 2024Pooled it
- Impact of sarcopenia on the future liver remnant growth after portal vein embolization and associating liver partition and portal vein ligation for staged hepatectomy in patients with liver cancer: A systematic review.Frontiers in oncology · 2022Pooled it
- Computed tomography-derived muscle quality and density and the risk of postoperative decline in exercise capacity in adults who received cardiac surgery: A retrospective cohort study.JPEN. Journal of parenteral and enteral nutrition · 2026Article
- Future of CT body composition research: Methodological discrepancies and advances.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Review
- Associations of paraspinal muscle quantity and quality with patient-reported outcomes in patients aged ≥85 years undergoing lumbar spine surgery: an exploratory retrospective study.Journal of spine surgery (Hong Kong) · 2026Article
- Sex-specific patterns of skeletal muscle aging at the L3 level: a quantitative study based on opportunistic CT.BMC musculoskeletal disorders · 2026Article
- The "fat heat-up" phenotype: adipose tissue hypermetabolism on 18 F-FDG PET/CT predicts frailty in older patients with solid tumours.European journal of nuclear medicine and molecular imaging · 2026Article
- Technical performance of L3 skeletal muscle area (SMA) measurement on CT for L3 skeletal muscle index (L3SMI) assessment.Scientific reports · 2026Article
- Automated CT-based visceral fat density predicts mortality regardless of visceral fat area.The British journal of radiology · 2026Article
- Reference Methods for Measuring Skeletal Muscle Mass: A Critical Perspective.Journal of cachexia, sarcopenia and muscle · 2026Review
- Influence of CT parameters upon the quantification of sarcopenia and myosteatosis: a study with human bodies.Scientific reports · 2026Article
- Article
- Intravenous contrast medium impairs CT-based muscle quality but not quantity assessment: a translational study.Frontiers in radiology · 2026Article
- Artificial intelligence-driven assessment of sarcopenia in orthopedic geriatrics: technical progress and clinical implications.Frontiers in endocrinology · 2026Review
- Myosteatosis: Epidemiological Insights, Functional Decline, and Diagnostic Advances.Current obesity reports · 2025Review
- Effects of Computed Tomography Technical Parameters on Body-Composition Analysis.Korean journal of radiology · 2025Review
- Myosteatosis is associated with advanced TNM stage and tumor features in young females with breast cancer.BMC cancer · 2025Article
- The Role of Muscle Density in Predicting the Amputation Risk in Peripheral Arterial Disease: A Tissue Composition Study Using Lower Extremity CT Angiography.Diagnostics (Basel, Switzerland) · 2025Article
- Comparing fully automated AI body composition biomarkers at differing virtual monoenergetic levels using dual-energy CT.Abdominal radiology (New York) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Computed tomography (CT) is a valuable assessment method for muscle pathologies such as sarcopenia, cachexia, and myosteatosis. However, several key underappreciated scan imaging parameters need consideration for both research and clinical use, specifically CT kilovoltage and the use of contrast material. We conducted a scoping review to assess these effects on CT muscle measures. We reviewed articles from PubMed, Scopus, and Web of Science from 1970 to 2020 on the effect of intravenous contrast material and variation in CT kilovoltage on muscle mass and density. We identified 971 articles on contrast and 277 articles on kilovoltage. The number of articles that met inclusion criteria for contrast and kilovoltage was 11 and 7, respectively. Ten studies evaluated the effect of contrast on muscle density of which nine found that contrast significantly increases CT muscle density (arterial phase 6-23% increase, venous phase 19-57% increase, and delayed phase 23-43% increase). Seven out of 10 studies evaluating the effect of contrast on muscle area found significant increases in area due to contrast (≤2.58%). Six studies evaluating kilovoltage on muscle density found that lower kilovoltage resulted in a higher muscle density (14-40% increase). One study reported a significant decrease in muscle area when reducing kilovoltage (2.9%). The use of contrast and kilovoltage variations can have dramatic effects on skeletal muscle analysis and should be considered and reported in CT muscle analysis research. These significant factors in CT skeletal muscle analysis can alter clinical and research outcomes and are therefore a barrier to clinical application unless better appreciated.
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Registered trials
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