Evidence map›Paper›PMID 36065447›Full record

ArticleFrontiers in immunology2022

Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report.

Haruna Akanuma, Takahiro Iizuka, Dan Abe, Kenji Yoshida, Nozomu Matsuda, Kotaro Sugimoto, Yuko Hashimoto, Kazuaki Kanai

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Haruna AkanumaDepartment of Neurology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Takahiro IizukaDepartment of Neurology, Kitasato University School of Medicine, Sagamihara, Japan.
Dan AbeDepartment of Neurology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Kenji YoshidaDepartment of Neurology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Nozomu MatsudaDepartment of Neurology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Kotaro SugimotoDepartment of Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Yuko HashimotoDepartment of Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Kazuaki KanaiDepartment of Neurology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Fukushima Medical University · JPKitasato University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is caused by a reversible inhibition of ion channel actions by autoantibodies and is associated with a relatively good prognosis. Pathological findings of NMDAR encephalitis usually do not show neurophagorous nodules, but rare or mild inflammatory infiltration. We report a patient of small cell lung cancer (SCLC)-related paraneoplastic encephalitis with NMDAR antibodies, a cytotoxic T-cell-mediated pathology of the brain, and a rapid clinical course. This case highlights that the neuropathological diversity of NMDAR encephalitis may be even broader than previously thought and that NMDAR antibodies may also be found in various pathological conditions with a vigorous immune response.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisLung NeoplasmsSmall Cell Lung CarcinomaAutoantibodiesHumansReceptors, N-Methyl-D-AspartateT-Lymphocytes, CytotoxicAutoantibodiesReceptors, N-Methyl-D-AspartateAnti-N-methyl-d-aspartate receptor antibodiescytotoxic T-cellsparaneoplastic encephalitispathologysmall cell lung cancer

Identifiers

PMID36065447
PMCPMC9440277
OpenAlexW4294104562

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.