Evidence map›Paper›PMID 36065353›Full record

ArticleMaterials today. Bio2022

Functional importance of coacervation to convert calcium polyphosphate nanoparticles into the physiologically active state.

Werner E G Müller, Meik Neufurth, Ingo Lieberwirth, Shunfeng Wang, Heinz C Schröder, Xiaohong Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  10. Reentrant DNA shells tune polyphosphate condensate size.bioRxiv : the preprint server for biology · 2023
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Werner E G MüllerERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128, Mainz, Germany.
Meik NeufurthERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128, Mainz, Germany.
Ingo LieberwirthMax Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Shunfeng WangERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128, Mainz, Germany.
Heinz C SchröderERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128, Mainz, Germany.
Xiaohong WangERC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, D-55128, Mainz, Germany.
Johannes Gutenberg University Mainz · DEMax Planck Institute for Polymer Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inorganic polyphosphates (polyP) are of increasing medical interest due to their unprecedented ability to exhibit both morphogenetic and ATP-delivering properties. However, these polymers are only physiologically active in the coacervate state, but not as amorphous nanoparticles (NP), the storage form of the polymer. Little is known about the mechanism of formation and interconversion of these two distinct polyP phases in the presence of metal ions. Based on in silico simulation studies, showing a differential clustering of polyP and calcium ions, the pH-dependent NP and coacervate formation of polyP was examined experimentally. Turbidimetric studies showed that Ca-polyP coacervate formation at pH 7 is a slow process compared to NP formation at pH 10. In FTIR spectra, the asymmetric stretching vibration signal of the internal (PO

Indexed as

ADK, adenylate kinaseAlkaline phosphataseALP, alkaline phosphataseAp5A, (P1,P5-di(adenosine-5′)pentaphosphateATPATP, adenosine triphosphateCa-polyP-Coa, calcium polyphosphate coacervateCa-polyP-NP, calcium polyphosphate nanoparticlesCoacervateECM, extracellular matrixFTIR, Fourier Transformed Infrared SpectroscopyInorganic polyphosphateLEV, levamisoleNanoparticlesNa-polyP, sodium polyphosphateNP, nanoparticlesPi, orthophosphatepolyP, polyphosphatePVA, poly(vinyl alcohol)SEM, scanning electron microscopyTEM, transmission electron microscopy

Identifiers

PMID36065353
PMCPMC9440442
OpenAlexW4293037454

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.