Evidence map›Paper›PMID 36065319›Full record

ArticleJournal of inflammation research2022

Chlorite-Oxidized Oxyamylose (COAM) Has Antibacterial Activity and Positively Affects Skin Wound Healing.

Rafaela Vaz Sousa Pereira, Estefania Ugarte-Berzal, Jennifer Vandooren, Karin Nylander, Erik Martens, Lieve Van Mellaert, Jo Van Damme, Jan Jeroen Vranckx, Patrick Matthys, Tiina Alamäe and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Rafaela Vaz Sousa PereiraDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.ORCID 0000-0003-3567-5262
Estefania Ugarte-BerzalDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Jennifer VandoorenDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Karin NylanderDepartment of Medical Cell Biology, Division of Integrative Physiology, Uppsala University, Uppsala, Sweden.
Erik MartensDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Lieve Van MellaertDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.ORCID 0000-0002-8584-8160
Jo Van DammeDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Jan Jeroen VranckxDepartment of Development & Regeneration & Department of Plastic & Reconstructive Surgery, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
Patrick MatthysDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Tiina AlamäeDepartment of Genetics, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Mia PhillipsonDepartment of Medical Cell Biology, Division of Integrative Physiology, Uppsala University, Uppsala, Sweden.
Triinu VisnapuuDepartment of Genetics, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.ORCID 0000-0003-1778-7949
Ghislain OpdenakkerDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1714-2294
Rega Institute for Medical Research · BEUniversity of Tartu · EEUppsala University · SEKU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To verify the antibacterial and immunomodulatory effects of the amylose derivative - chlorite-oxidized oxyamylose (COAM) - in a skin wound setting. Methods: In vitro antibacterial effects of COAM against opportunistic bacterial pathogens common to skin wounds, including Results: On the basis of in vitro experiments, an antibacterial effect of COAM against Conclusion: Aside from its known broad antiviral impact, COAM possesses in vitro antibacterial effects specifically against Gram-positive opportunistic pathogens of the skin and modulates in vivo macrophage contents in mouse skin wounds.

Indexed as

amylose derivativeantimicrobialmacrophagesneutrophilsStaphylococcuswound healing

Identifiers

PMID36065319
PMCPMC9440681
OpenAlexW4293535851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.