Evidence map›Paper›PMID 36065239›Full record

ArticleRadiology case reports2022

Early hepatocellular carcinoma developed within dysplastic nodule as nodule-within-nodule appearance: Case report with literature review.

Farid Aassouani, Fatima-Zahra Lkharrat, Yahya Charifi, Aicha Attar, Maria Lahlali, Nizar El Bouardi, Hakima Abid, Meryem Haloua, Badreeddine Alami, Meriem Boubbou and 2 more

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In one paragraph

Article in Radiology case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Farid AassouaniDepartment of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Fatima-Zahra LkharratDepartment of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Yahya CharifiDepartment of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Aicha AttarDepartment of Gastroenterology CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Maria LahlaliDepartment of Gastroenterology CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Nizar El BouardiDepartment of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Hakima AbidDepartment of Gastroenterology CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Meryem HalouaDepartment of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Badreeddine AlamiDepartment of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Meriem BoubbouDepartment of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Mustapha MaaroufiDepartment of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Moulay Youssef Alaoui LamraniDepartment of Radiology and Interventional Imaging, CHU Hassan II, FEZ, Sidi Mohammed Ben Abdellah University, Fez, Morocco.
Sidi Mohamed Ben Abdellah University · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Close follow-up of patients with liver cirrhosis has led to increased detection of hepatocellular carcinoma (HCC) at an early stage, especially with magnetic resonance imaging (MRI) innovations. We report the case of a 70-year-old man, with a recent history of liver cirrhosis due to chronic hepatitis C virus (HCV) complicated by hepatocellular carcinoma (HCC), and for whom trans-arterial chemoembolization (TACE) was planned, as the patient was assigned Child B7 at admission. Angiography performed during the first TACE cycle shows not only the "tumor blush" corresponding to previously detected HCC but also an additional small foci of HCC uptake seen within a large dysplastic nodule giving the appearance of "nodule-within-nodule." Early detection of hepatocellular carcinoma improves prognosis. Hence, it is essential to be aware of all early aspects of HCC, including the nodule-within-nodule appearance on cross-sectional imaging, and also in angiography, as in this case.

Indexed as

Alpha-FP, alpha-fetoproteinALT, Alanine amino-transferaseAST, aspartate aminotransferaseBP, blood pressureCBC, complete blood countChemoembolizationDSA, Digital subtraction angiographyDysplastic noduleEarly HCCHBV, hepatitis B virusHCC, hepatocellular carcinomaHCV-Ab, HCV antibodies. T1-WI, T1-weighted imagesHCV, hepatitis C virusHIV, human immunodeficiency virusLDH, lactate dehydrogenaseMRI, magnetic resonance imagingNodule-within-noduleNR, normal rangePR, Pulse ratePT, prothrombin timeRAHA, right anterior hepatic arteryRR, respiratory rateT2-WI, T2-weighted imagesTACE, trans-arterial chemoembolization

Identifiers

PMID36065239
PMCPMC9440365
OpenAlexW4293317100

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.