ArticleNature communications2022
The human thalamus orchestrates neocortical oscillations during NREM sleep.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- Slow Oscillation-Sleep Spindle Coupling Is Associated With Expectancy Measures of Fear Extinction Retention in Trauma-Exposed Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Human brain-wide activation of sleep rhythms.eLife · 2026Article
- Thalamic oscillations distinguish natural states of consciousness in humans.Nature human behaviour · 2026Article
- Effects of pulvinar and combined pulvinar/anterior thalamic deep-brain stimulation on sleep: preliminary results.Journal of neurology · 2026Article
- Clusters in Thalamic iEEG Spectral Features Reveal Sleep/Wake Differences Over Time.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2026Article
- Predictability of sleep slow oscillation emergence and spatial extent from pre-onset neural dynamics.Scientific reports · 2026Article
- Mediodorsal thalamus of alcohol-dependent mice shows genetic and physiological adaptations and alcohol-biased calcium signaling.Neuropharmacology · 2026Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.Communications biology · 2026Article
- Aperiodic and periodic neural activity during sleep in autism spectrum disorders.BMC medicine · 2026Article
- Winding down for the night: changes in thalamocortical connectivity before bed are associated with subsequent sleep-stage duration.Neuroreport · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Entrained cortical delta-spindle activity, not periodic synchrony, prevents arousal by NREM thalamic bursts.Communications biology · 2026Article
- Exploratory associations of sleep spindles and sleep disordered breathing indices with hippocampal and thalamic volume, and cortical thickness, and cerebrovascular biomarkers among community dwelling older adults: results from the Brain in Motion Study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Association of sleep pattern phenotypes with health outcomes in Chinese older chronic patients.BMC geriatrics · 2025Article
- Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons.Research square · 2025Article
- Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.Research square · 2025Article
- Thalamic involvement defines distinct slow-wave subtypes in NREM sleep.bioRxiv : the preprint server for biology · 2025Article
- Multimodal evidence of mediodorsal thalamus-prefrontal circuit dysfunctions in clinical high-risk for psychosis: findings from a combined 7T fMRI, MRSI and sleep Hd-EEG study.Molecular psychiatry · 2025Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A hallmark of non-rapid eye movement sleep is the coordinated interplay of slow oscillations (SOs) and sleep spindles. Traditionally, a cortico-thalamo-cortical loop is suggested to coordinate these rhythms: neocortically-generated SOs trigger spindles in the thalamus that are projected back to neocortex. Here, we used intrathalamic recordings from human epilepsy patients to test this canonical interplay. We show that SOs in the anterior thalamus precede neocortical SOs (peak -50 ms), whereas concurrently-recorded SOs in the mediodorsal thalamus are led by neocortical SOs (peak +50 ms). Sleep spindles, detected in both thalamic nuclei, preceded their neocortical counterparts (peak -100 ms) and were initiated during early phases of thalamic SOs. Our findings indicate an active role of the anterior thalamus in organizing sleep rhythms in the neocortex and highlight the functional diversity of thalamic nuclei in humans. The thalamic coordination of sleep oscillations could have broad implications for the mechanisms underlying memory consolidation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.