SynthesisTranslational psychiatry2022
Hyperthyroidism and clinical depression: a systematic review and meta-analysis.
Synthesis in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Pooled it
- Efficacy and safety ofFrontiers in pharmacology · 2025Pooled it
- High prevalence of erectile dysfunction in men with hyperthyroidism: a meta-analysis.BMC endocrine disorders · 2024Pooled it
- Treatment-Resistant Depression as a Heterogeneous Clinical Syndrome: A Personalized Medicine Framework for Diagnostic Reassessment, Suicide Risk, and Mechanism-Based Treatment.Journal of personalized medicine · 2026Review
- The Association of Thyroid Function on Cognition and Neuropsychiatric Symptoms in Patients with Cognitive Impairment.Neuropsychiatric disease and treatment · 2026Article
- Article
- Thyroid dysfunction in elderly first-episode drug-naïve major depressive disorder patients with comorbid dyslipidemia: prevalence, clinical profile and associated factors.Frontiers in psychiatry · 2025Article
- Evaluation of Neuro-Hormonal Dynamics after the Administration of Probiotic Microbial Strains in a Murine Model of Hyperthyroidism.Nutrients · 2024Article
- Somatic disease burden and depression risk in late life: a community-based study.Epidemiology and psychiatric sciences · 2024Article
- The Association between Depression, Anxiety, and Thyroid Disease: A UK Biobank Prospective Cohort Study.Depression and anxiety · 2024Article
- Association of thyroid function with abnormal lipid metabolism in young patients with first-episode and drug naïve major depressive disorder.Frontiers in psychiatry · 2023Article
- Article
- Overcoming treatment gaps in the management of depression with non-pharmacological adjunctive strategies.Frontiers in psychiatry · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperthyroidism and clinical depression are common, and there is preliminary evidence of substantial comorbidity. The extent of the association in the general population, however, has not yet been estimated meta-analytically. Therefore we conducted this systematic review and meta-analysis (registered in PROSPERO: CRD42020164791). Until May 2020, Medline (via PubMed), PsycINFO, and Embase databases were systematically searched for studies on the association of hyperthyroidism and clinical depression, without language or date restrictions. Two reviewers independently selected epidemiological studies providing laboratory or ICD-based diagnoses of hyperthyroidism and diagnoses of depression according to operationalized criteria (e.g. DSM) or to cut-offs in established rating scales. All data, including study quality based on the Newcastle-Ottawa Scale, were independently extracted by two authors. Odds ratios for the association of clinical depression and hyperthyroidism were calculated in a DerSimonian-Laird random-effects meta-analysis. Out of 3372 papers screened we selected 15 studies on 239 608 subjects, with 61% women and a mean age of 50. Relative to euthyroid individuals, patients with hyperthyroidism had a higher chance of being diagnosed with clinical depression: OR 1.67 ([95% CI: 1.49; 1.87], I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.