ArticleNPJ genomic medicine2022
A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility.
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Article in NPJ genomic medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Article
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- Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians.Aging cell · 2025Article
- A genetically based computational drug repurposing framework for rapid identification of candidate compounds: application to COVID-19.medRxiv : the preprint server for health sciences · 2025Article
- An exploratory analysis of associations of genetic variation with the efficacy of tocilizumab in severe COVID-19 patients. A pharmacogenetic study based on next-generation sequencing.Frontiers in pharmacology · 2024Article
- Evaluating the effects of circulating inflammatory proteins as drivers and therapeutic targets for severe COVID-19.Frontiers in immunology · 2024Article
- Host genetic polymorphisms involved in long-term symptoms of COVID-19.Emerging microbes & infections · 2023Article
- Integrating AI/ML Models for Patient Stratification Leveraging Omics Dataset and Clinical Biomarkers from COVID-19 Patients: A Promising Approach to Personalized Medicine.International journal of molecular sciences · 2023Article
- Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis.Frontiers in medicine · 2023Article
Corrections and comments
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Authors and funding
32 authors at 12 institutions in 1 country.
Georgios VoloudakisDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. georgios.voloudakis@mssm.edu.ORCID http://orcid.org/0000-0002-5729-632X
James M Vicari *Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4633-9961
Sanan Venkatesh *Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gabriel E Hoffman *Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kristina Dobrindt *Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6585-8513
Wen ZhangDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Noam D BeckmannDepartment of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christina A HigginsDepartment of Microbiology, Grossman School of Medicine, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0002-9865-148X
Stathis ArgyriouDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Shan JiangDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daisy HoaglandDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lina GaoBiostatistics Shared Resources, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0001-9382-0419
André CorveloNew York Genome Center, New York, NY, USA.
Kelly ChoVA Boston Healthcare System, Boston, MA, USA.
Kyung Min LeeVA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-8995-0448
Jiantao BianVA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.
Jennifer S LeeDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Sudha K IyengarDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Shiuh-Wen LuohVA Portland Health Care System, Portland, OR, USA.
Schahram AkbarianDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert StrikerDivision of Infectious Diseases, Department of Medicine, University of Wisconsin, Madison, WI, USA.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2349-0009
Eric E SchadtDepartment of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Julie A LynchVA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-0108-2127
Miriam MeradDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4481-7827
Benjamin R tenOeverDepartment of Microbiology, Grossman School of Medicine, New York University, New York, NY, USA.
Alexander W CharneyDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mount Sinai COVID-19 Biobank
VA Million Veteran Program COVID-19 Science Initiative
Kristen J BrennandDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0993-5956
John F FullardDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9874-2907
Panos RoussosDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. panagiotis.roussos@mssm.edu.ORCID http://orcid.org/0000-0002-4640-6239
Allen Institute for Brain Science · USIcahn School of Medicine at Mount Sinai · USNew York University · USOregon Health & Science University · USUniversity of Utah · USVA Palo Alto Health Care System · USBrigham and Women's Hospital · USNew York Genome Center · USSema4 (United States) · USUniversity of Wisconsin–Madison · USVA Northeast Ohio Healthcare System · USVA Salt Lake City Healthcare System · US
Funding
Understanding the molecular mechanisms that contribute to neuropsychiatric symptoms in Alzheimer DiseaseR01AG067025 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FINKBEINER, STEVEN M, HAROUTUNIAN, VAHRAM · 2019 to 2023
$11.8MHigher Order Chromatin and Genetic Risk for Alzheimer's DiseaseR01AG050986 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROUSSOS, PANAGIOTIS · 2015 to 2025
$11.2MUnderstanding the protective and neuroinflammatory role of human brain immune cells in Alzheimer DiseaseR01AG065582 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAROUTUNIAN, VAHRAM, ROUSSOS, PANAGIOTIS · 2020 to 2024
$9.9MINFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9MTeaching biomedical and pharmacological trainees to produce FAIR data for AI & ML applicationsT32GM062754 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SCHLESSINGER, AVNER · 2001 to 2023
$6.2MThe 3D genome in transcriptional regulation across the postnatal life span, with implications for schizophrenia and bipolar disorderU01MH116442 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, DRACHEVA, STELLA · 2018 to 2022
$5.9MRisk genetic variants and cis regulation of gene expression in Bipolar DisorderR01MH109677 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROUSSOS, PANAGIOTIS · 2016 to 2020
$4.6MFunctional genomic resource and integrative model of dopaminergic circuitry associated with psychiatric diseaseU01DA048279 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, BRENNAND, KRISTEN JENNIFER · 2019 to 2023
$3.5MCOVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MCharacterizing and targeting subphenotypes of schizophrenia and bipolar disorder via individually imputed tissue and cell-type specific transcriptomesK08MH122911 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI VOLOUDAKIS, GEORGIOS · 2020 to 2023
$770kBLRD VA I01 BX002395BLRD VA I01 BX004189NIAID NIH HHS T32 AI007180NIA NIH HHS R01 AG050986NIA NIH HHS R01 AG065582NIA NIH HHS R01 AG067025NIDA NIH HHS U01 DA048279NIGMS NIH HHS T32 GM062754NIH HHS S10 OD026880NIH HHS S10 OD030463NIMH NIH HHS K08 MH122911NIMH NIH HHS R01 MH109677NIMH NIH HHS U01 MH116442
Abstract
Recent efforts have identified genetic loci that are associated with coronavirus disease 2019 (COVID-19) infection rates and disease outcome severity. Translating these genetic findings into druggable genes that reduce COVID-19 host susceptibility is a critical next step. Using a translational genomics approach that integrates COVID-19 genetic susceptibility variants, multi-tissue genetically regulated gene expression (GReX), and perturbagen signatures, we identified IL10RB as the top candidate gene target for COVID-19 host susceptibility. In a series of validation steps, we show that predicted GReX upregulation of IL10RB and higher IL10RB expression in COVID-19 patient blood is associated with worse COVID-19 outcomes and that in vitro IL10RB overexpression is associated with increased viral load and activation of disease-relevant molecular pathways.
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