ArticleItalian journal of pediatrics2022
Physical growth and intelligence development of discordant dizygotic twins from birth to preschool age: a prospective cohort study.
Article in Italian journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- Early Infancy Weight Gain Patterns Are Associated with Child Body Mass Index in Singletons but Not Twins.The Journal of pediatrics · 2025Article
- Growth trajectories in monochorionic and dichorionic twins with weight discordance: a cohort study.European journal of pediatrics · 2025Article
- Association between birthweight discordance and extrauterine growth restriction among preterm twins: a national multi-center study in China.Frontiers in pediatrics · 2025Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
backgroundThe majority of studies are limited to adverse perinatal outcomes and poor cognitive abilities in the short term in discordant monochorionic twins.
methodsTo determine whether small and large discordant dizygotic twins differ in physical growth and intelligence development and weight and height from birth up to 6 years of age were measured in 34 dizygotic twin pairs with ≥ 20% birth weight discordance. Mental developmental index (MDI) and psychomotor developmental index (PDI) were calculated at 1 year, while the Wechsler Intelligence Scale for Children-IV (WISC-IV) full-scale intelligence quotient (IQ) was assessed at the age of 6.
resultsThe difference in height and weight in each stage differed significantly from birth to 72-months-old (P < 0.05), although there was disappointing catch-up growth in smaller twins. PDI but not MDI at 1 year of age was significantly different between the two groups (P < 0.05), and smaller twins experienced higher psychomotor retardation rates (P < 0.05). Also, the influence of height and weight on PDI was statistically significant (P < 0.05). No significant difference was detected in the WISC-IV full-scale IQ at the age of 6; however, the full-scale IQ may be affected by the history of suffocation and the S/D value (P = 0.011, P = 0.022).
conclusionsIntrauterine fetal growth and development lead to birth weight differences in twins and sustain an impact on the children's physical growth in height and weight from birth to preschool age, causing psychomotor developmental differences at 1 year of age. However, the differences in psychomotor development decrease gradually by the age of 6.
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