ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2022
Medial Prefrontal Cortex Activity to Reward Outcome Moderates the Association Between Victimization Due to Sexual Orientation and Depression in Youth.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 13 citations in OpenAlex.
- Continuous theta burst stimulation to dorsomedial prefrontal cortex in young adults with depression: Changes in resting frontostriatal functional connectivity relevant to positive mood.Behaviour research and therapy · 2024Trial
- Adolescents' ventral striatal reward neural activity moderates the association between lifetime trauma exposure and lower depression after 6 months.European journal of psychotraumatology · 2026Article
- Low Emotional Awareness and Altered Frontostriatal Functional Connectivity During Reward Processing Prospectively Predict Depressive Symptoms in At-Risk Youth.Journal of child and adolescent psychopharmacology · 2026Article
- Neighborhood socioeconomic status and adolescent brain responses to peer feedback: Testing relationships with negative and positive affect assessed outside of the lab.Development and psychopathology · 2026Article
- Neural response to reward as a potential pathway from inflammation to anhedonia in adolescents at risk for depression.Brain, behavior, & immunity - health · 2026Article
- Psychotic-like experiences in adolescents enriched for high-risk for developing severe mental illness: change over two-years and associations with neural reward processing and affective symptoms.European archives of psychiatry and clinical neuroscience · 2026Article
- Interpersonal Contributors to Depression in Sexual Minority Adolescents: An Examination of Exposure to Acute Stressors and Neural Reactivity to Interpersonal Emotional Images.Developmental psychobiology · 2026Article
- Understanding suicide in sexual minority youth: neural reactivity to social cues as a moderating influence.Cognitive, affective & behavioral neuroscience · 2025Article
- Weighing the predictive role of neural factors for adolescent anhedonia in the presence of demographic and clinical factors.Journal of mood and anxiety disorders · 2025Article
- Bioethical and critical consciousness in clinical translational neuroscience.Journal of clinical and translational science · 2025Review
- Two-year trajectories of anhedonia in adolescents at transdiagnostic risk for severe mental illness: Association with clinical symptoms and brain-symptom links.Journal of psychopathology and clinical science · 2024Article
- The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research.Molecular psychiatry · 2024Review
- Annual Research Review: Puberty and the development of anhedonia - considering childhood adversity and inflammation.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Anhedonia in adolescents at transdiagnostic familial risk for severe mental illness: Clustering by symptoms and mechanisms of association with behavior.Journal of affective disorders · 2024Article
- Sleep disturbance and social reward processing as characteristics linking minority victimization and suicidal ideation in youth.Frontiers in neuroscience · 2024Article
- The relationship between changes in functional connectivity gradients and cognitive-emotional disorders in sudden sensorineural hearing loss.Brain communications · 2024Article
- Diversity, Equity, and Inclusivity in Biological Psychiatry Research.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundSexual minority youth (SMY) are 3 times more likely to experience depression than heterosexual peers. Minority stress theory posits that this association is explained by sexual orientation victimization, which acts as a stressor to impact depression. For those vulnerable to the effects of stress, victimization may worsen depression by altering activity in neural reward systems. This study examines whether neural reward systems moderate the influence of sexual orientation victimization, a common and distressing experience in SMY, on depression.
methodsA total of 81 participants ages 15 to 22 years (41% SMY, 52% marginalized race) reported sexual orientation victimization, depression severity, and anhedonia severity, and underwent a monetary reward functional magnetic resonance imaging task. Significant activation to reward > neutral outcome (p
resultsSMY reported higher depression (p < .001), anhedonia (p = .03), and orientation victimization (p < .001) than heterosexual youth. The bilateral ventral striatum, medial prefrontal cortex (mPFC), anterior cingulate cortex, and right orbitofrontal cortex were significantly active to reward. mPFC activation moderated associations between sexual orientation victimization and depression (p = .03), with higher depression severity observed in those with a combination of higher mPFC activation and greater orientation victimization.
conclusionsSexual orientation victimization was related to depression but only in the context of higher mPFC activation, a pattern observed in depressed youth. These novel results provide evidence for neural reward sensitivity as a vulnerability factor for depression in SMY, suggesting mechanisms for disparities, and are a first step toward a clinical neuroscience understanding of minority stress in SMY.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.